Effect of the new silicon-based agent on the symptoms of interstitial pneumonitis.
Shimada M, Koyama Y, Kobayashi Y, Kobayashi H, Shimada S. · Scientific Reports. 2023;13:32745.
Study at a glance
Preclinical
Mice in a methotrexate-associated interstitial-pneumonitis model.
Dietary silicon-based hydrogen-generating agent before and during the pneumonitis protocol. · A directly administered H2 dose was not measured.
Dietary pretreatment and model follow-up as reported in the article.
Several fibrosis, macrophage and oxidative measures favored the supplemented group, while some macroscopic and oxidative endpoints did not differ.
Animal evidence only; effects of the silicon product cannot be assigned exclusively to hydrogen.
What kind of evidence is this?
Preclinical
Controlled mouse study
Respiratory health
Other forms
Mixed positive preclinical signal.
Animal lung tissue and biomarker outcomes.
Methods
Mice in a methotrexate-associated interstitial-pneumonitis model.
Four study groups; the article reports model-specific group sizes in the methods and figures.
Dietary pretreatment and model follow-up as reported in the article.
Dietary silicon-based hydrogen-generating agent before and during the pneumonitis protocol.
Hydrogen generated in the gastrointestinal tract by a silicon-based dietary agent; not Brown's gas.
A directly administered H2 dose was not measured.
Control diet with and without the pneumonitis model.
Outcomes and reported result
Lung fibrosis and histology, macrophage infiltration and oxidative-stress markers.
Several fibrosis, macrophage and oxidative measures favored the supplemented group, while some macroscopic and oxidative endpoints did not differ.
The full article, methods, figures and positive and null outcomes were checked.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Animal evidence only; effects of the silicon product cannot be assigned exclusively to hydrogen.
The reported mouse pneumonitis model.
SYRCLE animal-study tool — preliminary
Some concerns
Allocation concealment and assessor blinding were not clearly reported.
Randomization/allocation reporting is limited · Blinding of personnel is unclear · Attrition is incompletely reported in places · Blinding of outcome assessors is unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 37029197 · DOI: 10.1038/s41598-023-32745-8
Free full article in PubMed Central.
PubMed record and PubMed Central full text; extraction checked 9 August 2026.
10 August 2026
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