Hydrogen Promotes the Effectiveness of Bone Mesenchymal Stem Cell Transplantation in Rats with Spinal Cord Injury
Luo S, Wu J, Qiu Y, Xiao B, Xi Y, Yang C, Shi Z, Wang W. · 2023.
Study at a glance
Preclinical
Rats with experimental spinal-cord injury and cultured bone-marrow mesenchymal stem cells.
Hydrogen-rich saline with or without bone-marrow mesenchymal stem-cell transplantation. · 0.6 mmol/L; 5 mL/kg at the reported repeated schedule.
Repeated treatment with follow-up through 28 days.
The combined hydrogen-saline and stem-cell condition was reported to improve cell viability, locomotor scores and tissue or molecular measures versus injury controls.
Animal and cell evidence only; the combination design cannot isolate all effects of hydrogen.
What kind of evidence is this?
Preclinical
Controlled rat and cell study
Other neurological conditions
Other forms
Positive preclinical signal; combination arm emphasized.
Animal functional, tissue and cell-mechanistic outcomes.
Methods
Rats with experimental spinal-cord injury and cultured bone-marrow mesenchymal stem cells.
Animal and cell groups were checked in the full article; assay-specific counts vary.
Repeated treatment with follow-up through 28 days.
Hydrogen-rich saline with or without bone-marrow mesenchymal stem-cell transplantation.
H₂ dissolved in saline.
0.6 mmol/L; 5 mL/kg at the reported repeated schedule.
Injury controls, hydrogen-saline and stem-cell treatment arms.
Outcomes and reported result
Locomotor function, spinal histology, cell survival and molecular markers.
The combined hydrogen-saline and stem-cell condition was reported to improve cell viability, locomotor scores and tissue or molecular measures versus injury controls.
The full article was checked for methods, intervention details, outcomes, positive and null findings, funding and conflicts. This record does not imply medical efficacy.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Animal and cell evidence only; the combination design cannot isolate all effects of hydrogen.
The reported rat spinal-injury and cell models only.
SYRCLE animal-study tool — preliminary
Some concerns
Controls were present, but concealment, assessor blinding and selective-outcome risk were unclear.
Sequence generation checked where reported · Allocation concealment generally unclear · Personnel blinding generally unclear · Outcome-assessor blinding generally unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 37181828 · DOI: 10.1155/2023/8227382
A free full article is available through PubMed Central.
Official PubMed Central full article and PubMed bibliographic record; source identity, methods, intervention, results, funding and conflicts checked 10 August 2026.
10 August 2026
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