Inhaled molecular hydrogen reduces hippocampal neuroinflammation, glial reactivity and ameliorates memory impairment during systemic inflammation
de Deus JL, Amorim MR, da Silva Junior RMP, Jesus AA, de Barcellos Filho PCG, Cárnio EC, Cunha AOS, Leão RM, Branco LGS. · Brain, behavior, & immunity - health. 2023;31:100654.
Study at a glance
Preclinical
rats, cell, tissue, rat used to study other neurological conditions.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 2%, 21%, 20 min, 2 L/min, 77%. · H₂-related quantities reported in the intervention passages: 2%, 21%, 20 min, 2 L/min, 77%. Values are not combined across different experimental arms.
20 min
Article-reported result excerpt (24 words maximum): “1]A–D; LPS + Air) were significantly reduced in animals that inhaled H_2 ([Fig.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Other neurological conditions
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, cell, tissue, rat used to study other neurological conditions.
Preclinical study; group or assay counts reported in the full text include n=25, n=23, n=22, n=8, n=4, n=5.
20 min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 2%, 21%, 20 min, 2 L/min, 77%.
Inhaled molecular H₂ at 2%; oxygen co-delivery is reported.
H₂-related quantities reported in the intervention passages: 2%, 21%, 20 min, 2 L/min, 77%. Values are not combined across different experimental arms.
40 mL/min H₂, calculated from 2% H₂ and 2000 mL/min total flow reported in the full text.
21% O₂; 420 mL/min O₂ calculated from the reported total flow.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “1]A–D; LPS + Air) were significantly reduced in animals that inhaled H_2 ([Fig.” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 37449286 · DOI: 10.1016/j.bbih.2023.100654
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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