APOA2: New Target for Molecular Hydrogen Therapy in Sepsis-Related Lung Injury Based on Proteomic and Genomic Analysis
Wang Y, Fan Y, Jiang Y, Wang E, Song Y, Chen H, Xu F, Xie K, Yu Y. · International journal of molecular sciences. 2023;24(14):11325.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Respiratory health
Inhaled H₂
Not reported in this record.
Not reported in this record.
Methods at a glance
mice, tissues, tissue, rabbit used to study respiratory health.
Preclinical study; group or assay counts reported in the full text include n=20, n=5, n=10.
Multiple article-specific time points; see the linked full methods.
Full text reports inhaled H₂-containing gas. No numeric quantity is inferred beyond the source wording.
Inhaled molecular H₂; not classified as Brown’s gas without an H₂/O₂ composition.
The full article describes the H₂ intervention but does not report a numeric H₂ concentration.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Placebo or matched control reported in the full article.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “In the next ELISA experiment [Figure 7]B, Apoa2 protein levels were found to be down-regulated after the CLP model ( p -value < 0.05,…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 37511084 · DOI: 10.3390/ijms241411325
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10