Hydrogen therapy promotes macrophage polarization to the M2 subtype in radiation lung injury by inhibiting the NF-κB signalling pathway
Gao X, Niu S, Li L, Zhang X, Cao X, Zhang X, Pan W, Sun M, Zhao G, Zheng X, Song G, Zhang Y. · Heliyon. 2024;10(10):e30902.
Study at a glance
Preclinical
mice, mouse, tissues, tissue used to study respiratory health.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 2 weeks, 5 weeks, 4 %. · H₂-related quantities reported in the intervention passages: 2 weeks, 5 weeks, 4 %. Values are not combined across different experimental arms.
2 weeks
Article-reported result excerpt (24 words maximum): “Treatment group 1 showed a trend of remission relative to the model group, but it was not statistically significant, and the recovery of the…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Respiratory health
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, mouse, tissues, tissue used to study respiratory health.
Preclinical study; the full text reports 6 mice, with group/assay counts including n=3.
2 weeks
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 2 weeks, 5 weeks, 4 %.
Inhaled molecular H₂ at 4%; not classified as Brown’s gas without an H₂/O₂ composition.
H₂-related quantities reported in the intervention passages: 2 weeks, 5 weeks, 4 %. Values are not combined across different experimental arms.
Not reported in the full article — an absolute H₂ flow in mL/min could not be verified.
O₂ concentration and absolute O₂ flow were not both reported in the full article; no value is inferred.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “Treatment group 1 showed a trend of remission relative to the model group, but it was not statistically significant, and the recovery of the…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 38826750 · DOI: 10.1016/j.heliyon.2024.e30902
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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