Hydrogen gas improves proliferation and mitochondrial activity of human adipose-derived stem cells after cryopreservation
Kimura K, Tabata Y. · Regenerative therapy. 2024;26:571-577.
Study at a glance
Preclinical
cell, cells used to study metabolic and lipid health.
Full text reports H₂ dissolved in another reported solution. Detected intervention quantities or schedules: 1 mM, 3.7%, 20 min, 3 mm. · H₂-related quantities reported in the intervention passages: 1 mM, 3.7%, 20 min, 3 mm. Values are not combined across different experimental arms.
20 min
Article-reported result excerpt (24 words maximum): “2 Proliferation profile of hADSC cryopreserved in the presence (〇) or absence of hydrogen gas (●) 0, 24, 48, 72 and 96 h (A)…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Controlled cell or tissue study
Metabolic and lipid health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
cell, cells used to study metabolic and lipid health.
Preclinical study; the article does not state one consolidated sample total, so no total is inferred.
20 min
Full text reports H₂ dissolved in another reported solution. Detected intervention quantities or schedules: 1 mM, 3.7%, 20 min, 3 mm.
H₂ dissolved in another reported solution — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 1 mM, 3.7%, 20 min, 3 mm. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “2 Proliferation profile of hADSC cryopreserved in the presence (〇) or absence of hydrogen gas (●) 0, 24, 48, 72 and 96 h (A)…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 39246699 · DOI: 10.1016/j.reth.2024.08.004
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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