Clinical Observation of Hydrogen-Rich Saline for Nasal Irrigation After Surgery for Chronic sinusitis:A Randomized, Double-Blind, Controlled Trial
Jin L, Fan K, Yao C, Chang Y, Wang Y, Lu J, Yu S. · Journal of inflammation research. 2024;17:7361-7372.
Study at a glance
Human
Human participants studied for other molecular hydrogen research. See eligibility criteria in the linked full text.
Full text reports H₂ dissolved in saline. Detected intervention quantities or schedules: 100mL. · H₂-related quantities reported in the intervention passages: 100mL. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “There were no significant differences in baseline indicators between the two groups, including gender, age, disease duration, affected side, polyps, preoperative VAS score of…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Human
Randomized blinded controlled study
Other molecular hydrogen research
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for other molecular hydrogen research. See eligibility criteria in the linked full text.
Human study; the full text reports 64 patients, with group/assay counts including n=31, n=30.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in saline. Detected intervention quantities or schedules: 100mL.
H₂ dissolved in saline — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 100mL. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “There were no significant differences in baseline indicators between the two groups, including gender, age, disease duration, affected side, polyps, preoperative VAS score of…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this other molecular hydrogen research article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 39429848 · DOI: 10.2147/jir.s476646
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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