Molecular Hydrogen Therapy in Aneurysmal SAH With RA and Newly-diagnosed SLE, Complicated With Acute Ischemic Infarction: A Case Report of Improved Immune Markers Including Tr1 Cells, Breg Cells and TIM3 Expression on Tc Cells
Chen JY, Lu JW, Feng SW, Ho YJ, Lui SW, Hsieh TY, Liu FC. · In vivo (Athens, Greece). 2024;38(6):3131-3137.
Study at a glance
Human
One woman with aneurysmal subarachnoid hemorrhage, rheumatoid arthritis and newly diagnosed systemic lupus erythematosus complicated by acute ischemic infarction.
One oral H₂-generating capsule per day, initiated on 16 January 2024 as adjunctive therapy. · Each capsule contained 170 mg hydrogen-rich coral calcium and was described as providing approximately 1.7×10²¹ hydrogen molecules. The article gives a theoretical equivalence to 24 cups of water at 1,200 ppb or 0.6 mM per 200 mL; those are not directly administered water doses.
Daily from 16 January 2024 through the reported follow-up.
Article-reported result excerpt (24 words maximum): “Among these findings, the most notable was the Tr1 cells, whose levels decreased before hospitalization and then gradually increased as the patient’s condition improved…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Human
Case report
Oral and dental health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
One woman with aneurysmal subarachnoid hemorrhage, rheumatoid arthritis and newly diagnosed systemic lupus erythematosus complicated by acute ischemic infarction.
Single-patient case report.
Daily from 16 January 2024 through the reported follow-up.
One oral H₂-generating capsule per day, initiated on 16 January 2024 as adjunctive therapy.
an oral H₂-generating preparation — H₂ only unless the full text explicitly reports oxygen co-delivery.
Each capsule contained 170 mg hydrogen-rich coral calcium and was described as providing approximately 1.7×10²¹ hydrogen molecules. The article gives a theoretical equivalence to 24 cups of water at 1,200 ppb or 0.6 mM per 200 mL; those are not directly administered water doses.
No concurrent control; before-and-after observations in one patient receiving extensive concurrent treatment.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “Among these findings, the most notable was the Tr1 cells, whose levels decreased before hospitalization and then gradually increased as the patient’s condition improved…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies only to the population and protocol reported in this oral and dental health article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 39477420 · DOI: 10.21873/invivo.13799
A free full article is available through PubMed Central.
Official PubMed/PMC full article; record re-audited and corrected 25 August 2026.
25 August 2026
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