Molecular Hydrogen Modulates T Cell Differentiation and Enhances Neuro-Regeneration in a Vascular Dementia Mouse Model
Lee D, Jo H, Choi JI. · Antioxidants (Basel, Switzerland). 2025;14(1):111.
Study at a glance
Preclinical
mouse, mice, tissues, tissue used to study other neurological conditions.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 5%, 1.000 ppm. · H₂-related quantities reported in the intervention passages: 5%, 1.000 ppm. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “This tendency was reversed in the H_2-treated group (n = 14) compared to the VaD group ( p = 0.0475), with no difference between…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Other neurological conditions
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mouse, mice, tissues, tissue used to study other neurological conditions.
Preclinical study; group or assay counts reported in the full text include n=15, n=18, n=14, n=13, n=12, n=11.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 5%, 1.000 ppm.
H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 5%, 1.000 ppm. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “This tendency was reversed in the H_2-treated group (n = 14) compared to the VaD group ( p = 0.0475), with no difference between…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model for other neurological conditions, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 39857445 · DOI: 10.3390/antiox14010111
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
29 September 2026
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