Pharmacokinetics of Hydrogen During Hydrogen-Saturated Saline Infusion in Pigs
Shibuya M, Fujinaka M, Yonezawa M, Nishimura N, Uchinoumi H, Sunahara H, Tani K, Kobayashi E, Sano M. · Biomedicines. 2025;13(1):234.
Study at a glance
Preclinical
pigs, pig used to study cardiovascular and circulatory health.
Full text reports an injected or infused H₂ intervention. Detected intervention quantities or schedules: 1 mL, 3 mL/kg, 120 min, 30 min, 60 min, 90 min, 500 mL, 8 weeks. · H₂-related quantities reported in the intervention passages: 1 mL, 3 mL/kg, 120 min, 30 min, 60 min, 90 min, 500 mL, 8 weeks. Values are not combined across different experimental arms.
120 min
Article-reported result excerpt (24 words maximum): “The analysis of the hydrogen-saturated saline showed that the color of the solution was clear and colorless, the pH was 5.6, and the sodium…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Cardiovascular and circulatory health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
pigs, pig used to study cardiovascular and circulatory health.
Preclinical study; the article does not state one consolidated sample total, so no total is inferred.
120 min
Full text reports an injected or infused H₂ intervention. Detected intervention quantities or schedules: 1 mL, 3 mL/kg, 120 min, 30 min, 60 min, 90 min, 500 mL, 8 weeks.
an injected or infused H₂ intervention — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 1 mL, 3 mL/kg, 120 min, 30 min, 60 min, 90 min, 500 mL, 8 weeks. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, apoptosis or cell injury, histology or tissue damage, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “The analysis of the hydrogen-saturated saline showed that the color of the solution was clear and colorless, the pH was 5.6, and the sodium…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 39857817 · DOI: 10.3390/biomedicines13010234
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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