Molecular hydrogen ameliorates anti-desmoglein 1 antibody-induced pemphigus-associated interstitial lung disease by inhibiting oxidative stress
Tang C et al. · Int J Mol Sci. 2025;26(9):4203.
Study at a glance
Preclinical
BALB/cJGpt mice receiving anti-desmoglein-1 or anti-desmoglein-3 antibodies
1.6 ppm hydrogen-rich drinking water, replaced daily, after induction of the anti-Dsg1 lung-disease model · 1.6 ppm dissolved H₂, verified by gas chromatography.
One week for inflammatory/oxidative assessments and three weeks for fibrosis assessments
The article reports less inflammation, fibrosis and early oxidative stress with H₂-rich water. IgG deposition was not changed, and ROS did not significantly differ after three weeks.
Novel antibody-transfer mouse model with many molecular endpoints and no human participants; the authors acknowledge industry support for the H₂-rich water supply.
What kind of evidence is this?
Preclinical
Controlled antibody-transfer mouse interstitial-lung-disease experiment with one- and three-week assessments
Respiratory health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
BALB/cJGpt mice receiving anti-desmoglein-1 or anti-desmoglein-3 antibodies
Several control, antibody-model and H₂-water groups were used; the complete article does not report one total mouse count or consistent group size
One week for inflammatory/oxidative assessments and three weeks for fibrosis assessments
1.6 ppm hydrogen-rich drinking water, replaced daily, after induction of the anti-Dsg1 lung-disease model
H₂ dissolved in drinking water — H₂ only, not Brown’s gas and not inhalation.
1.6 ppm dissolved H₂, verified by gas chromatography.
Model mice receiving normal water, water-only controls and antibody-specific groups
Outcomes and reported result
Lung histology, collagen and Ashcroft score, IgG deposition, inflammatory and profibrotic genes, ROS and antioxidant-gene expression
The article reports less inflammation, fibrosis and early oxidative stress with H₂-rich water. IgG deposition was not changed, and ROS did not significantly differ after three weeks.
The complete open-access article was checked for water concentration, model groups, time points, positive and null outcomes, funding and conflicts. A single total animal count is not reported.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Novel antibody-transfer mouse model with many molecular endpoints and no human participants; the authors acknowledge industry support for the H₂-rich water supply.
Anti-Dsg1-induced interstitial lung disease in mice, not pemphigus-associated lung disease treatment in people.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 40362440 · DOI: 10.3390/ijms26094203
Open-access full text is available through PMC and the publisher.
Open-access PMC article and PubMed record; no retraction or expression of concern was shown in the checked records on 7 August 2026.
10 August 2026
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