Efficacy of silicon-based agent against aging-related frailty.
Koyama Y, Kobayashi Y, Kobayashi H, Shimada S. · Scientific Reports. 2026;16:39711.
What kind of evidence is this?
Preclinical
Controlled mouse studies
Skin, wound and aging research
Other forms
Mixed preclinical signal.
Animal functional and survival outcomes.
Methods at a glance
Klotho-deficient mice and very old male C57BL/6J mice.
Klotho experiment began with 20 mice per group; aged-mouse batches included 21 control and 20 supplemented mice.
Three weeks in the klotho model and approximately nine weeks in aged mice.
Diet containing 1.0% or 2.5% silicon-based hydrogen-generating agent, depending on experiment.
Hydrogen generated in the gastrointestinal tract by a silicon-based dietary agent; not Brown's gas.
A directly administered molecular-H2 dose was not measured.
Not applicable — dietary agent.
No oxygen was co-delivered.
Matched control diet.
Outcomes and reported result
Frailty-related behavior, balance, body weight and survival.
Several frailty and functional measures favored supplementation; the full-period survival comparison was not statistically significant.
The full article, both animal models, figures, exclusions and significant and null survival findings were checked.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Animal evidence only. Some deaths occurred before behavioral testing, and silicon-product effects cannot be assigned exclusively to hydrogen.
The two reported mouse aging models.
SYRCLE animal-study tool — preliminary
Some concerns
Deaths before testing and incomplete reporting of concealment and assessor blinding create attrition and measurement concerns.
Randomization/allocation reporting is limited · Blinding of personnel is unclear · Attrition is incompletely reported in places · Blinding of outcome assessors is unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 41688516 · DOI: 10.1038/s41598-026-39711-0
Free full article in PubMed Central.
PubMed record and PubMed Central full text; extraction checked 9 August 2026.
2026-08-10