Efficacy of silicon-based agent against aging-related frailty.
Koyama Y, Kobayashi Y, Kobayashi H, Shimada S. · Scientific Reports. 2026;16:39711.
Molecular hydrogen (H2) and Skin, wound and aging research
Browse 31 source-checked skin, wound and aging research records involving molecular hydrogen (H2), with human and preclinical evidence clearly separated.
31full-text-checked records
9human studies
22animal and laboratory records
No treatment conclusion is impliedHealing, symptoms, objective skin measures and cosmetic outcomes require different interpretations. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.
Hydrogen gas therapy: A promising approach for sepsis management post-burn injury by modulating inflammation, oxidative stress, and wound healing
Yu P, Hong N, Wang G, Chen S, Zhao Z. · CytoJournal. 2025;22:46.
Hydrogen-Releasing Micromaterial Dressings: Promoting Wound Healing by Modulating Extracellular Matrix Accumulation Through Wnt/β-Catenin and TGF-β/Smad Pathways
Zhao P, Li Y, Guo B, Liu Z, Zhang X, Liu M, Ma X. · Pharmaceutics. 2025;17(3):279.
Hydrogen-Rich Saline Combined With Vacuum Sealing Drainage Promotes Wound Healing by Altering Biotin Metabolism
Kuang X, Liang Z, Xia Y, Shan M, Hao Y, Liu H, Wang Z, He Q, Xia C, Feng C, Chang G, Wang Y. · Journal of Cellular and Molecular Medicine. 2025;29(1):e70292.
Molecular hydrogen reduces dermatitis-induced itch, diabetic itch and cholestatic itch through a SIRT1–β-catenin pathway in mice
Zhang L et al. · Redox Biol. 2025;79:103472.
Multifunctional PdH-hydride MOFs for synergistic hydrogen and photothermal antibacterial therapy in accelerated wound healing
Wang Q, Zhang D, Qi Y, Huang C, Ding D, Liu C. · Frontiers in pharmacology. 2025;16:1587890.
Spontaneous hydrogen-releasing nanoenzyme alleviates osteoarthritis via oxidative stress reduction and mitochondrial dysfunction reversal
Wang Q, Zhang M, Jiang W, Li D, Qi B, Shi S, Shi S, Yi C. · Journal of nanobiotechnology. 2025;23(1):662.
Sustained-release photothermal microneedles for postoperative incisional analgesia and wound healing via hydrogen therapy
Zhang A, Jiang X, Xiong B, Chen J, Liu X, Wang S, Li B, Peng M, Li W. · Advanced Science. 2025;12(35):e03698.
Topically Applied Molecular Hydrogen Normalizes Skin Parameters Associated with Oxidative Stress: A Pilot Study
Debkowska N et al. · Antioxidants (Basel). 2025;14(6):729.
Hydrogen inhalation: A novel approach to alleviating allergic rhinitis symptoms by modulating nasal flora^[☆]
Wang N, Ma Q, Zhai J, Che Y, Liu J, Tang T, Sun Y, Wang J, Yang W. · The World Allergy Organization journal. 2024;17(10):100970.
Mast Cells in Regeneration of the Skin in Burn Wound with Special Emphasis on Molecular Hydrogen Effect
Atiakshin D, Soboleva M, Nikityuk D, Alexeeva N, Klochkova S, Kostin A, Shishkina V, Buchwalow I, Tiemann M. · Pharmaceuticals (Basel, Switzerland). 2023;16(3):348.
Molecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and extracellular matrix deposition
Zhao P, Dang Z, Liu M, Guo D, Luo R, Zhang M, Xie F, Zhang X, Wang Y, Pan S, Ma X. · Inflammation and regeneration. 2023;43(1):22.
Effect of hydrogen intervention on refractory wounds after radiotherapy: A case report.
Zhao PX, Luo RL, Dang Z, Wang YB, Zhang XJ, Liu ZY, Wen XH, Liu MY, Zhang MZ, Adzavon YM, Ma XM. · 2022.
Hydrogen-generating Si-based agent protects against skin flap ischemia-reperfusion injury in rats.
Otani N, Tomita K, Kobayashi Y, Kuroda K, Koyama Y, Kobayashi H, Kubo T. · Scientific Reports. 2022;12:10228.
Hydrogen-Rich Water Prevents Dehydration-Induced Cellular Oxidative Stress and Cell Death in Human Skin Keratinocytes
Xiao L, Miwa N. · Hydrogen. 2022;3(1):20–31.
Repetitive Bathing and Skin Poultice with Hydrogen-Rich Water Improve Wrinkles and Blotches Together with Modulation of Skin Oiliness and Moisture
Tanaka Y, Miwa N. · Hydrogen. 2022;3(2):161–177.
Antioxidant activity of hydrogen water mask pack composed of gel-type emulsion and hydrogen generation powder
Kwon HJ, Han SB, Park KW. · International Journal of Molecular Sciences. 2020;21(24):9731.
Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles
Asada R, Saitoh Y, Miwa N. · Medical Gas Research. 2019;9(2):68–73.
Electrolytically generated hydrogen warm water cleanses the keratin-plug-clogged hair-pores and promotes the capillary blood-streams, more markedly than normal warm water does.
Tanaka Y, Saitoh Y, Miwa N. · 2018.
Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells
Zhang B, Zhao Z, Meng X, Chen H, Fu G, Xie K. · Int J Mol Med. 2018;41(6):3653–3661.
Hydrogen gas inhalation protects against cutaneous ischaemia/reperfusion injury in a mouse model of pressure ulcer
Fang W, Wang G, Tang L, Su H, Chen H, Liao W, Xu J. · Journal of cellular and molecular medicine. 2018;22(9):4243-4252.
Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques
Zhu Q, Wu Y, Li Y, Chen Z, Wang L, Xiong H, Dai E, Wu J, Fan B, Ping L, Luo X. · Scientific Reports. 2018;8:8051.
Hydrogen gas protects IP3Rs by reducing disulfide bridges in human keratinocytes under oxidative stress
Wu CY, Hsu WL, Tsai MH, Liang JL, Lu JH, Yen CJ, Yu HS, Noda M, Lu CY, Chen CH, Yan SJ, Yoshioka T. · Scientific Reports. 2017;7:3606.
Hydrogen treatment protects against cell death and senescence induced by oxidative damage
Han AL, Park SH, Park MS. · J Microbiol Biotechnol. 2017;27(2):365–371.