Protective Effects of Hydrogen Treatment Against High Glucose-Induced Oxidative Stress and Apoptosis via Inhibition of the AGEs/RAGE/NF-κB Signaling Pathway in Skin Cells
Yu P, Hong N, Wu Q, Zhao Z. · Endocrine, metabolic & immune disorders drug targets. 2025;25(14):1177-1190.
Study at a glance
Preclinical
cells, cell used to study metabolic and lipid health.
Full text reports another explicitly administered H₂ intervention. Detected intervention quantities or schedules: 72 hours, 60%, 40%, 20%. · H₂-related quantities reported in the intervention passages: 72 hours, 60%, 40%, 20%. Values are not combined across different experimental arms.
72 hours
Article-reported result excerpt (24 words maximum): “The experimental results demonstrated that a 60% H_2 concentration at 48 and 72 h enhanced cell activity more effectively than aminoguanidine, an inhibitor of…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled cell or tissue study
Metabolic and lipid health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
cells, cell used to study metabolic and lipid health.
Preclinical study; the article does not state one consolidated sample total, so no total is inferred.
72 hours
Full text reports another explicitly administered H₂ intervention. Detected intervention quantities or schedules: 72 hours, 60%, 40%, 20%.
another explicitly administered H₂ intervention — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 72 hours, 60%, 40%, 20%. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “The experimental results demonstrated that a 60% H_2 concentration at 48 and 72 h enhanced cell activity more effectively than aminoguanidine, an inhibitor of…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 39791170 · DOI: 10.2174/0118715303369584241231141001
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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