Hydrogen-Generating Silica Material Prevents UVA-Ray-Induced Cellular Oxidative Stress, Cell Death, Collagen Loss and Melanogenesis in Human Cells and 3D Skin Equivalents
Xiao L, Mochizuki M, Nakahara T, Miwa N. · Antioxidants (Basel, Switzerland). 2021;10(1):76.
Study at a glance
Preclinical
cell, tissue, cells, mouse used to study cancer research.
Full text reports an H₂-releasing or H₂-generating intervention. Detected intervention quantities or schedules: 10 days, 0.025%, 0.01%, 5 min, 10 min, 10%, 250 µM, 1%, 4 weeks, 3 days. · H₂-related quantities reported in the intervention passages: 10 days, 0.025%, 0.01%, 5 min, 10 min, 10%, 250 µM, 1%, 4 weeks, 3 days. Values are not combined across different experimental arms.
10 days
Article-reported result excerpt (24 words maximum): “Before the experiments, we first examined the cytotoxicity of ULH-002 and found out that ULH-002 did not have significant cytotoxicity under the concentration of…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Cancer research
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
cell, tissue, cells, mouse used to study cancer research.
Preclinical study; group or assay counts reported in the full text include n=5.
10 days
Full text reports an H₂-releasing or H₂-generating intervention. Detected intervention quantities or schedules: 10 days, 0.025%, 0.01%, 5 min, 10 min, 10%, 250 µM, 1%, 4 weeks, 3 days.
an H₂-releasing or H₂-generating intervention — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 10 days, 0.025%, 0.01%, 5 min, 10 min, 10%, 250 µM, 1%, 4 weeks, 3 days. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, oxidative-stress and antioxidant markers, apoptosis or cell injury, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “Before the experiments, we first examined the cytotoxicity of ULH-002 and found out that ULH-002 did not have significant cytotoxicity under the concentration of…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 33430157 · DOI: 10.3390/antiox10010076
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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