Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice
Otani N, Oue T, Kobayashi Y, Kobayashi H, Tomita K, Kubo T. · Biomedicines. 2025;13(10):2475.
Study at a glance
Preclinical
mice, mouse, tissue, cells used to study oral and dental health.
Full text reports an H₂-releasing or H₂-generating intervention. Detected intervention quantities or schedules: 3 days, 5%, 30 min. · H₂-related quantities reported in the intervention passages: 3 days, 5%, 30 min. Values are not combined across different experimental arms.
3 days
Article-reported result excerpt (24 words maximum): “Quantitative scoring of HE sections confirmed significantly lower tissue damage scores ( p < 0.05) in both Si-treated groups in comparison to controls ([Figure…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Oral and dental health
Other forms
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, mouse, tissue, cells used to study oral and dental health.
Preclinical study; group or assay counts reported in the full text include n=9, n=8.
3 days
Full text reports an H₂-releasing or H₂-generating intervention. Detected intervention quantities or schedules: 3 days, 5%, 30 min.
an H₂-releasing or H₂-generating intervention — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 3 days, 5%, 30 min. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “Quantitative scoring of HE sections confirmed significantly lower tissue damage scores ( p < 0.05) in both Si-treated groups in comparison to controls ([Figure…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 41153760 · DOI: 10.3390/biomedicines13102475
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
10 August 2026
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