Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water
Xue J, Shang G, Tanaka Y, Saihara Y, Hou L, Velasquez N, Liu W, Lu Y. · 2014.
Study at a glance
Preclinical
Rats with experimentally induced gastric mucosal injury.
Alkaline electrolyzed drinking water prepared with graded dissolved-hydrogen concentrations. · Reported comparison included 0, 0.07, 0.22 and 0.84 ppm dissolved H₂ with differing pH conditions.
Acute gastric-injury protocol.
Gastric injury was reported to be lower with higher dissolved hydrogen, while differing pH conditions complicate attribution.
Animal evidence only; pH and other electrolyzed-water properties may confound the hydrogen comparison.
What kind of evidence is this?
Preclinical
Controlled rat gastric-injury study
Gastrointestinal health
H₂-rich water
Dose-related positive preclinical signal with water-chemistry confounding.
Animal gastric-tissue outcomes with dose and pH comparisons.
Methods
Rats with experimentally induced gastric mucosal injury.
Group counts were checked in the full article; no consolidated total is inferred.
Acute gastric-injury protocol.
Alkaline electrolyzed drinking water prepared with graded dissolved-hydrogen concentrations.
H₂ dissolved in drinking water.
Reported comparison included 0, 0.07, 0.22 and 0.84 ppm dissolved H₂ with differing pH conditions.
Water conditions differing in hydrogen concentration and pH.
Outcomes and reported result
Gastric lesion area and related tissue or oxidative measures.
Gastric injury was reported to be lower with higher dissolved hydrogen, while differing pH conditions complicate attribution.
The full article was checked for methods, intervention details, outcomes, positive and null findings, funding and conflicts. This record does not imply medical efficacy.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Animal evidence only; pH and other electrolyzed-water properties may confound the hydrogen comparison.
The reported rat gastric-injury and water-preparation conditions only.
SYRCLE animal-study tool — preliminary
Some concerns
Dose controls were included, but concealment, assessor blinding and isolation of pH effects were unclear.
Sequence generation checked where reported · Allocation concealment generally unclear · Personnel blinding generally unclear · Outcome-assessor blinding generally unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 24589018 · DOI: 10.1186/1472-6882-14-81
A free full article is available through PubMed Central.
Official PubMed Central full article and PubMed bibliographic record; source identity, methods, intervention, results, funding and conflicts checked 10 August 2026.
10 August 2026
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