Protective effect of inhalation of hydrogen gas on radiation-induced dermatitis and skin injury in rats
Watanabe S, Fujita M, Ishihara M, Tachibana S, Yamamoto Y, Kaji T, Kawauchi T, Kanatani Y. · Journal of radiation research. 2014;55(6):1107-1113.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Cancer research
Inhaled H₂
Not reported in this record.
Not reported in this record.
Methods at a glance
rats, rat, tissues, tissue used to study cancer research.
Preclinical study; group or assay counts reported in the full text include n=14.
2 l/min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 1.3%, 20.8%, 77.9%, 300 mm, 2 l/min, 0.3%, 15 min.
Inhaled molecular H₂ at 0.3%; oxygen co-delivery is reported.
H₂-related quantities reported in the intervention passages: 1.3%, 20.8%, 77.9%, 300 mm, 2 l/min, 0.3%, 15 min. Values are not combined across different experimental arms.
6 mL/min H₂, calculated from 0.3% H₂ and 2000 mL/min total flow reported in the full text.
20.8% O₂; 416 mL/min O₂ calculated from the reported total flow.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “Significant differences in wound-healing rate were also observed in the different HCG inhalation groups following 20-Gy irradiation (Fig. [2]A and B): the pre-inhalation group…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 25034733 · DOI: 10.1093/jrr/rru067
A free full article is available through PubMed Central.
Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.
2026-08-10