Protective effect of inhalation of hydrogen gas on radiation-induced dermatitis and skin injury in rats
Watanabe S, Fujita M, Ishihara M, Tachibana S, Yamamoto Y, Kaji T, Kawauchi T, Kanatani Y. · Journal of radiation research. 2014;55(6):1107-1113.
Study at a glance
Preclinical
rats, rat, tissues, tissue used to study cancer research.
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 1.3%, 20.8%, 77.9%, 300 mm, 2 l/min, 0.3%, 15 min. · H₂-related quantities reported in the intervention passages: 1.3%, 20.8%, 77.9%, 300 mm, 2 l/min, 0.3%, 15 min. Values are not combined across different experimental arms.
2 l/min
Article-reported result excerpt (24 words maximum): “Significant differences in wound-healing rate were also observed in the different HCG inhalation groups following 20-Gy irradiation (Fig. [2]A and B): the pre-inhalation group…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Cancer research
Inhaled H₂
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, rat, tissues, tissue used to study cancer research.
Preclinical study; group or assay counts reported in the full text include n=14.
2 l/min
Full text reports inhaled H₂-containing gas. Detected intervention quantities or schedules: 1.3%, 20.8%, 77.9%, 300 mm, 2 l/min, 0.3%, 15 min.
Inhaled molecular H₂ at 0.3%; oxygen co-delivery is reported.
H₂-related quantities reported in the intervention passages: 1.3%, 20.8%, 77.9%, 300 mm, 2 l/min, 0.3%, 15 min. Values are not combined across different experimental arms.
6 mL/min H₂, calculated from 0.3% H₂ and 2000 mL/min total flow reported in the full text.
20.8% O₂; 416 mL/min O₂ calculated from the reported total flow.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “Significant differences in wound-healing rate were also observed in the different HCG inhalation groups following 20-Gy irradiation (Fig. [2]A and B): the pre-inhalation group…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 25034733 · DOI: 10.1093/jrr/rru067
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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