Hydrogenology
Hydrogenology editorial study record

Positive effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice

Yoon YS, Sajo ME, Ignacio RM, Kim SK, Kim CS, Lee KJ. · Biol Pharm Bull. 2014;37(9):1480–1485.

PreclinicalH₂-rich waterPublished 2014
Study record, not medical adviceThis page reports one source and Hydrogenology’s source-text extraction. It does not establish that molecular hydrogen is effective, safe or appropriate for any person. Human, animal and laboratory evidence must not be treated as equivalent.
Source and classification

What kind of evidence is this?

Evidence stream

Preclinical

Reported design

Controlled mouse study

Research topic

Skin, wound and aging research

Administration classification

H₂-rich water

Study result signal

Positive preclinical signal.

Outcome type

Clinical-appearance, tissue and inflammatory outcomes in mice.

Reported in the source

Methods at a glance

Population or model

Mice in an induced atopic-dermatitis model.

Sample

Group sizes were checked in the full article.

Duration

Article-specific dermatitis protocol.

Intervention

Hydrogen-rich water during dermatitis induction.

Hydrogen form

H₂ dissolved in drinking water.

H₂ specification

Article-specific preparation and exposure concentration.

H₂ flow

Not applicable — drinking water.

O₂ delivered with H₂

No oxygen was co-delivered.

Comparator

Model animals receiving control water and non-model controls.

Reported, not endorsed

Outcomes and reported result

Outcomes measured

Dermatitis severity, inflammatory markers and skin histology.

Reported result

Dermatitis severity and several inflammatory and tissue measures favored hydrogen-rich water in the reported model.

Results-extraction completeness

The full article methods, intervention, outcomes, positive and null findings, funding and conflict statements were checked.

A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.

Interpretation limits

Cautions and applicability

Design and reporting cautions

Animal-model evidence only.

Applies directly to

The reported mouse dermatitis model only.

Preliminary appraisal framework

SYRCLE animal-study tool — preliminary

Preliminary risk-of-bias status

Some concerns

Appraisal rationale

Controls were reported, while sequence generation and assessor blinding were unclear.

Appraisal domains

Sequence generation checked where reported · Allocation concealment generally unclear · Personnel blinding generally unclear · Outcome-assessor blinding generally unclear · No prospectively registered analysis plan identified

No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.

Provenance

Sources and record status

Identifiers

PMID: 25177031 · DOI: 10.1248/bpb.b14-00220

Publisher access

A free publisher or repository full article was checked.

Extraction basis

Publisher or repository full article and bibliographic record; checked 10 August 2026.

Record revision

2026-08-10

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