Positive effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice
Yoon YS, Sajo ME, Ignacio RM, Kim SK, Kim CS, Lee KJ. · Biol Pharm Bull. 2014;37(9):1480–1485.
Study at a glance
Preclinical
Mice in an induced atopic-dermatitis model.
Hydrogen-rich water during dermatitis induction. · Article-specific preparation and exposure concentration.
Article-specific dermatitis protocol.
Dermatitis severity and several inflammatory and tissue measures favored hydrogen-rich water in the reported model.
Animal-model evidence only.
What kind of evidence is this?
Preclinical
Controlled mouse study
Skin, wound and aging research
H₂-rich water
Positive preclinical signal.
Clinical-appearance, tissue and inflammatory outcomes in mice.
Methods
Mice in an induced atopic-dermatitis model.
Group sizes were checked in the full article.
Article-specific dermatitis protocol.
Hydrogen-rich water during dermatitis induction.
H₂ dissolved in drinking water.
Article-specific preparation and exposure concentration.
Model animals receiving control water and non-model controls.
Outcomes and reported result
Dermatitis severity, inflammatory markers and skin histology.
Dermatitis severity and several inflammatory and tissue measures favored hydrogen-rich water in the reported model.
The full article methods, intervention, outcomes, positive and null findings, funding and conflict statements were checked.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Animal-model evidence only.
The reported mouse dermatitis model only.
SYRCLE animal-study tool — preliminary
Some concerns
Controls were reported, while sequence generation and assessor blinding were unclear.
Sequence generation checked where reported · Allocation concealment generally unclear · Personnel blinding generally unclear · Outcome-assessor blinding generally unclear · No prospectively registered analysis plan identified
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 25177031 · DOI: 10.1248/bpb.b14-00220
A free publisher or repository full article was checked.
Publisher or repository full article and bibliographic record; checked 10 August 2026.
10 August 2026
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