Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study
Azuma T et al. · Antioxidants (Basel). 2015;4(3):513–522.
Study at a glance
Human
Adults with periodontitis
Hydrogen-rich water, 200–300 mL per serving, 4–5 times/day; 1,000 mL/day total · Generated with a metallic magnesium stick; the article does not report a numeric dissolved-H₂ concentration.
8 weeks; periodontal treatment at weeks 2 and 4
Several periodontal measures improved more in the seven-person H₂-water group, and total antioxidant capacity increased at week 4. The pilot was extremely small and open label.
Only 13 participants, open-label design, several repeated measurements and active periodontal treatment in both groups. Public research grants funded the work; authors declared no conflicts.
What kind of evidence is this?
Human
Randomized controlled open-label pilot study
Oral and dental health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Adults with periodontitis
13 participants: H₂ water n=7; control n=6
8 weeks; periodontal treatment at weeks 2 and 4
Hydrogen-rich water, 200–300 mL per serving, 4–5 times/day; 1,000 mL/day total
H₂ dissolved in water — H₂ only, not Brown’s gas.
Generated with a metallic magnesium stick; the article does not report a numeric dissolved-H₂ concentration.
Standard oral-hygiene instruction and non-surgical periodontal treatment without H₂ water
Outcomes and reported result
Probing pocket depth, clinical attachment level, gingival measures and serum oxidative-stress measures
Several periodontal measures improved more in the seven-person H₂-water group, and total antioxidant capacity increased at week 4. The pilot was extremely small and open label.
Dose, methods, results, funding and conflicts checked in the open-access full text; numeric H₂ concentration was not reported.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Only 13 participants, open-label design, several repeated measurements and active periodontal treatment in both groups. Public research grants funded the work; authors declared no conflicts.
Adults with periodontitis receiving standard non-surgical periodontal care; not H₂-water monotherapy.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 26783840 · DOI: 10.3390/antiox4030513
Open-access full text is available through PMC and the publisher.
Open-access PMC and publisher full texts plus PubMed record.
10 August 2026
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