Hydrogenology editorial study record

Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study

Azuma T et al. · Antioxidants (Basel). 2015;4(3):513–522.

HumanH₂-rich waterPublished 2015

Study record, not medical adviceThis page reports one source and Hydrogenology’s source-text extraction. It does not establish that molecular hydrogen is effective, safe or appropriate for any person. Human, animal and laboratory evidence must not be treated as equivalent.

Source and classification

What kind of evidence is this?

Evidence stream

Human

Reported design

Randomized controlled open-label pilot study

Research topic

Oral and dental health

Administration classification

H₂-rich water

Study result signal

Not reported in this record.

Outcome type

Not reported in this record.

Reported in the source

Methods at a glance

Population or model

Adults with periodontitis

Sample

13 participants: H₂ water n=7; control n=6

Duration

8 weeks; periodontal treatment at weeks 2 and 4

Intervention

Hydrogen-rich water, 200–300 mL per serving, 4–5 times/day; 1,000 mL/day total

Hydrogen form

H₂ dissolved in water — H₂ only, not Brown’s gas.

H₂ specification

Generated with a metallic magnesium stick; the article does not report a numeric dissolved-H₂ concentration.

H₂ flow

Not applicable — oral water, not gas inhalation.

O₂ delivered with H₂

No O₂ was co-delivered as part of the intervention.

Comparator

Standard oral-hygiene instruction and non-surgical periodontal treatment without H₂ water

Reported, not endorsed

Outcomes and reported result

Outcomes measured

Probing pocket depth, clinical attachment level, gingival measures and serum oxidative-stress measures

Reported result

Several periodontal measures improved more in the seven-person H₂-water group, and total antioxidant capacity increased at week 4. The pilot was extremely small and open label.

Results-extraction completeness

Dose, methods, results, funding and conflicts checked in the open-access full text; numeric H₂ concentration was not reported.

A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.

Interpretation limits

Cautions and applicability

Design and reporting cautions

Only 13 participants, open-label design, several repeated measurements and active periodontal treatment in both groups. Public research grants funded the work; authors declared no conflicts.

Applies directly to

Adults with periodontitis receiving standard non-surgical periodontal care; not H₂-water monotherapy.

Preliminary appraisal framework

Not reported in this record.

Preliminary risk-of-bias status

Not reported in this record.

Appraisal rationale

Not reported in this record.

No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.

Provenance

Sources and record status

Identifiers

PMID: 26783840 · DOI: 10.3390/antiox4030513

Publisher access

Open-access full text is available through PMC and the publisher.

Extraction basis

Open-access PMC and publisher full texts plus PubMed record.

Record revision

2026-08-10

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