Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model
Tamaki N, Orihuela-Campos RC, Fukui M, Ito HO. · Oxidative medicine and cellular longevity. 2016;2016:5679040.
Study at a glance
Preclinical
rats, rat, tissue, cell used to study oral and dental health.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 7 days, 7 ppm, 500 mL, 1 ppm. · H₂-related quantities reported in the intervention passages: 7 days, 7 ppm, 500 mL, 1 ppm. Values are not combined across different experimental arms.
7 days
Article-reported result excerpt (24 words maximum): “These results indicate that hydrogen-rich water intake reduced systemic nitrosative and oxidative stresses by the activation of antioxidant activity..” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled preclinical study
Oral and dental health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
rats, rat, tissue, cell used to study oral and dental health.
Preclinical study; group or assay counts reported in the full text include n=6.
7 days
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 7 days, 7 ppm, 500 mL, 1 ppm.
H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 7 days, 7 ppm, 500 mL, 1 ppm. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage
Article-reported result excerpt (24 words maximum): “These results indicate that hydrogen-rich water intake reduced systemic nitrosative and oxidative stresses by the activation of antioxidant activity..” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 26798423 · DOI: 10.1155/2016/5679040
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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