Hydrogen-rich water protects against inflammatory bowel disease in mice by inhibiting endoplasmic reticulum stress and promoting heme oxygenase-1 expression
Shen NY et al. · World J Gastroenterol. 2017;23(8):1375-1386.
Study at a glance
Preclinical
mice, tissue, mouse, cells used to study gastrointestinal health.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 5%. · H₂-related quantities reported in the intervention passages: 5%. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “The disease activity index observably increased after DSS treatment, and the DSS + HRW group exhibited a lower extent of disease than the DSS…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Controlled animal and cell study
Gastrointestinal health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, tissue, mouse, cells used to study gastrointestinal health.
Preclinical study; group or assay counts reported in the full text include n=6.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 5%.
H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 5%. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “The disease activity index observably increased after DSS treatment, and the DSS + HRW group exhibited a lower extent of disease than the DSS…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. No funding statement was identified in the machine-readable full article; absence is not inferred. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 28293084 · DOI: 10.3748/wjg.v23.i8.1375
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
Help people check the facts before they buy.
Hydrogenology keeps 665 source-checked records accessible without advertising or product promotion.
Help us correct the recordReport a discrepancy
Send the exact difference between this page and the linked source. The study reference is attached automatically.