Hydrogenology
Hydrogenology editorial study record

The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats

Zhou P, Lin B, Wang P, Pan T, Wang S, Chen W, Cheng S, Liu S. · Journal of radiation research. 2019;60(1):17-22.

PreclinicalH₂-rich waterPublished 2019
Study record, not medical adviceThis page reports one source and Hydrogenology’s source-text extraction. It does not establish that molecular hydrogen is effective, safe or appropriate for any person. Human, animal and laboratory evidence must not be treated as equivalent.
Source and classification

What kind of evidence is this?

Evidence stream

Preclinical

Reported design

Controlled preclinical study

Research topic

Cancer research

Administration classification

H₂-rich water

Study result signal

Not reported in this record.

Outcome type

Not reported in this record.

Reported in the source

Methods at a glance

Population or model

rats, tissue used to study cancer research.

Sample

Preclinical study; the article does not state one consolidated sample total, so no total is inferred.

Duration

Multiple article-specific time points; see the linked full methods.

Intervention

Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 1.0 ppm, 2.0 ppm.

Hydrogen form

H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.

H₂ specification

H₂-related quantities reported in the intervention passages: 1.0 ppm, 2.0 ppm. Values are not combined across different experimental arms.

H₂ flow

Not applicable — no inhaled H₂ intervention was identified in the full article.

O₂ delivered with H₂

No inhaled O₂ co-delivery was identified for this non-inhalation intervention.

Comparator

Control or comparison condition reported in the full article; see the linked methods for arm-specific details.

Reported, not endorsed

Outcomes and reported result

Outcomes measured

clinical symptoms or functional scores, tumor growth or cancer markers, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, metabolic laboratory measures

Reported result

Article-reported result excerpt (24 words maximum): “MDA content and SOD activity in wound tissue: hydrogen-rich water decreased the MDA content (A) and increased the SOD activity (B) in rats with…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.

Results-extraction completeness

The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.

A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.

Interpretation limits

Cautions and applicability

Design and reporting cautions

Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.

Applies directly to

Applies to the reported animal, cell or tissue model, not directly to patients.

Preliminary appraisal framework

Not reported in this record.

Preliminary risk-of-bias status

Not reported in this record.

Appraisal rationale

Not reported in this record.

No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.

Provenance

Sources and record status

Identifiers

PMID: 30260398 · DOI: 10.1093/jrr/rry074

Publisher access

A free full article is available through PubMed Central.

Extraction basis

Official Europe PMC JATS full article and PubMed/PMC identifiers; structured full-text extraction and validation completed 8 August 2026.

Record revision

2026-08-10

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