Assessment of the effects of hydrogen water on human gingival fibroblast cell culture in patients with chronic periodontitis
Bhatt A, Nayak A, Bhat K, Bogar C, Nayak R, Naik S. · Journal of Indian Society of Periodontology. 2023;27(3):278-282.
Study at a glance
Human
Human participants studied for immune and inflammatory conditions. See eligibility criteria in the linked full text.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 2.4 ml. · H₂-related quantities reported in the intervention passages: 2.4 ml. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “Hydrogen water-treated fibroblasts from chronic periodontitis patients (CF) 13 0.275 0.004 0.276 . *Statistically highly significant difference ( P <0.01). n – Number of…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
What kind of evidence is this?
Human
Human interventional or observational study
Immune and inflammatory conditions
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Human participants studied for immune and inflammatory conditions. See eligibility criteria in the linked full text.
Human study; the full text reports 26 subjects.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 2.4 ml.
H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 2.4 ml. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
survival or mortality, oxidative-stress and antioxidant markers, apoptosis or cell injury
Article-reported result excerpt (24 words maximum): “Hydrogen water-treated fibroblasts from chronic periodontitis patients (CF) 13 0.275 0.004 0.276 . *Statistically highly significant difference ( P <0.01). n – Number of…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Human evidence; design, sample size and comparator limit interpretation. Funding or grant information is reported in the full article. No explicit conflict statement was identified in the machine-readable full article; absence is not inferred.
Applies only to the population and protocol reported in this immune and inflammatory conditions article.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 37346858 · DOI: 10.4103/jisp.jisp_546_21
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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