A Novel Therapy for Cisplatin-Induced Allodynia and Dysfunctional and Emotional Impairments in Male and Female Mice
Martínez-Martel I, Pol O · Antioxidants (Basel). 2023;12(12):2063.
What kind of evidence is this?
Preclinical
Controlled sex-stratified mouse chemotherapy-toxicity experiment
Musculoskeletal and pain research
H₂-rich water
Not reported in this record.
Not reported in this record.
Methods at a glance
Male and female C57BL/6J mice receiving cisplatin
Behavioral groups n=8; molecular analyses n=3 samples/group
30 days
Prophylactic hydrogen-rich drinking water for 30 consecutive days
H₂ dissolved in drinking water — H₂ only, not Brown’s gas and not inhalation.
Numeric H₂ concentration was not identified in the extracted full-text passages.
Not applicable — oral water, not gas inhalation.
No O₂ was co-delivered as part of the intervention.
Cisplatin- and vehicle-treated mice receiving ordinary water
Outcomes and reported result
Mechanical and cold allodynia, grip strength, body weight, anxiety- and depressive-like behavior, inflammation and oxidative-stress proteins
The article reports prevention of pain-like, functional and emotional changes in both sexes and lower selected inflammatory or oxidative-stress signals.
Behavioral, sex-stratified and molecular results checked in the open-access full text; numeric H₂ concentration remains to be confirmed.
A reported association, difference or mechanism is not automatically a clinical benefit. Null findings, outcome type, study design and precision all matter.
Cautions and applicability
Mouse model, prophylactic rather than therapeutic design, small molecular samples and many outcomes. It does not establish prevention of cisplatin neuropathy in people.
Male and female mice receiving cisplatin, not cancer patients.
Not reported in this record.
Not reported in this record.
Not reported in this record.
No single-study GRADE certainty rating is assigned. Certainty is assessed by important outcome across a complete eligible evidence set, not by attaching a final grade to one source.
Sources and record status
PMID: 38136183 · DOI: 10.3390/antiox12122063
Open-access full text is available through PMC.
Open-access PMC full text and PubMed record.
2026-08-10