A Novel Therapy for Cisplatin-Induced Allodynia and Dysfunctional and Emotional Impairments in Male and Female Mice
Martínez-Martel I, Pol O · Antioxidants (Basel). 2023;12(12):2063.
Study at a glance
Preclinical
Male and female C57BL/6J mice receiving cisplatin
Prophylactic hydrogen-rich drinking water for 30 consecutive days · Numeric H₂ concentration was not identified in the extracted full-text passages.
30 days
The article reports prevention of pain-like, functional and emotional changes in both sexes and lower selected inflammatory or oxidative-stress signals.
Mouse model, prophylactic rather than therapeutic design, small molecular samples and many outcomes. It does not establish prevention of cisplatin neuropathy in people.
What kind of evidence is this?
Preclinical
Controlled sex-stratified mouse chemotherapy-toxicity experiment
Musculoskeletal and pain research
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Male and female C57BL/6J mice receiving cisplatin
Behavioral groups n=8; molecular analyses n=3 samples/group
30 days
Prophylactic hydrogen-rich drinking water for 30 consecutive days
H₂ dissolved in drinking water — H₂ only, not Brown’s gas and not inhalation.
Numeric H₂ concentration was not identified in the extracted full-text passages.
Cisplatin- and vehicle-treated mice receiving ordinary water
Outcomes and reported result
Mechanical and cold allodynia, grip strength, body weight, anxiety- and depressive-like behavior, inflammation and oxidative-stress proteins
The article reports prevention of pain-like, functional and emotional changes in both sexes and lower selected inflammatory or oxidative-stress signals.
Behavioral, sex-stratified and molecular results checked in the open-access full text; numeric H₂ concentration remains to be confirmed.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Mouse model, prophylactic rather than therapeutic design, small molecular samples and many outcomes. It does not establish prevention of cisplatin neuropathy in people.
Male and female mice receiving cisplatin, not cancer patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 38136183 · DOI: 10.3390/antiox12122063
Open-access full text is available through PMC.
Open-access PMC full text and PubMed record.
10 August 2026
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