Hydrogen-rich water alleviates neuropathic pain through the modulation of bile acid/Takeda G-protein-coupled receptor 5-mediated autophagy
Zeng X et al. · Pain. 2026;167(3):663–677.
Molecular hydrogen (H2) and Musculoskeletal and pain research
Browse 26 source-checked musculoskeletal and pain research records involving molecular hydrogen (H2), with human and preclinical evidence clearly separated.
26full-text-checked records
3human studies
23animal and laboratory records
No treatment conclusion is impliedSubjective symptoms, function, recovery, tissue outcomes and laboratory markers are kept distinct. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.
Molecular Hydrogen Reverses Nociplastic Pain and Depressive-like Behaviors via Region- and Sex-Dependent Central Mechanisms
Negrini-Ferrari SE et al. · Int J Mol Sci. 2026;27(7):3051.
A Case Report of Adjuvant Molecular Hydrogen Therapy in Refractory Rheumatoid Arthritis With Atlantoaxial Subluxation.
Ren YC, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. · In Vivo. 2025;39:14166.
Degradation products of magnesium implant synergistically enhance bone regeneration: Unraveling the roles of hydrogen gas and alkaline environment
An Y, Zhang H, Zhang S, Zhang Y, Zheng L, Chen X, Tong W, Xu J, Qin L. · Bioactive materials. 2025;46:331-346.
Hydrogen-oxygen mixture inhalation as an adjunctive treatment to home-based exercise in older patients with knee osteoarthritis
Wang C et al. · Front Pharmacol. 2025;16:1505922.
Hydrogen-Rich Water Potentiates Cannabinoid- and Gabapentinoid-Induced Analgesia in Neuropathic Pain
Tort NA, Negrini-Ferrari SE, Pol O. · International journal of molecular sciences. 2025;26(24):12155.
Nrf2/HO-1-sulfiredoxin1 pathway involved in nanobubble hydrogen-dissolved water-mediated protective effects by ultrasound-guided early local injection in a rat model of chronic constriction injury-induced neuropathic pain
Yu J, Yin Z, Ma H, Zhang B, Meng C. · Frontiers in molecular neuroscience. 2025;18:1666575.
A more accurate indicator to evaluate oxidative stress in rat plasma with osteoporosis[†]
Dong WC, Guo JL, Jiang XH, Xu L, Wang H, Ni XY, Zhang YZ, Zhang ZQ, Jiang Y. · 2023.
A Novel Therapy for Cisplatin-Induced Allodynia and Dysfunctional and Emotional Impairments in Male and Female Mice
Martínez-Martel I, Pol O · Antioxidants (Basel). 2023;12(12):2063.
Hydrogen attenuates postoperative pain through Trx1/ASK1/MMP9 signaling pathway
Li J et al. · J Neuroinflammation. 2023;20(1):22.
Molecular hydrogen prevents osteoclast activation in a glucocorticoid-induced osteoporosis zebrafish scale model
Carnovali M, Banfi G, Mariotti M. · Antioxidants. 2023;12(2):345.
Therapeutic Potential of Hydrogen-Rich Water on Muscle Atrophy Caused by Immobilization in a Mouse Model
Nazari SE et al. · Pharmaceuticals (Basel). 2023;16(10):1436.
Hydrogen saline water accelerates fracture healing by suppressing autophagy in ovariectomized rats
Guo J, Tian S, Wang Z, Wang Y, Zhang X, Zhang Y, Hou Z, Dong W. · 2022.
Hydrogen-Rich Saline Attenuates Chronic Allodynia after Bone Fractures via Reducing Spinal CXCL1/CXCR2-Mediated Iron Accumulation in Mice
Wang Y et al. · Brain Sci. 2022;12(12):1610.
Treatment with Hydrogen-Rich Water Improves the Nociceptive and Anxio-Depressive-like Behaviors Associated with Chronic Inflammatory Pain in Mice
Coral-Pérez S, Martínez-Martel I, Martínez-Serrat M, Batallé G, Bai X, Leite-Panissi CRA, Pol O. · Antioxidants (Basel, Switzerland). 2022;11(11):2153.
Drinking Hydrogen-Rich Water Alleviates Chemotherapy-Induced Neuropathic Pain Through the Regulation of Gut Microbiota
Lian N et al. · J Pain Res. 2021;14:681–691.
Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice
Hasegawa S, Ito M, Fukami M, Hashimoto M, Hirayama M, Ohno K. · Redox Report. 2017;22(1):26-34.
Hydrogen-rich saline attenuates steroid-associated femoral head necrosis through inhibition of oxidative stress in a rabbit model
Huang SL, Jiao J, Yan HW. · Experimental and Therapeutic Medicine. 2016;11(1):177-182.
Molecular hydrogen decelerates rheumatoid arthritis progression through inhibition of oxidative stress
Meng J, Yu P, Jiang H, Yuan T, Liu N, Tong J, Chen H, Bao N, Zhao J. · American Journal of Translational Research. 2016;8(10):4472–4477.
The effect of hydrogen gas evolution of magnesium implant on the postimplantation mortality of rats
Noviana D, Paramitha D, Ulum MF, Hermawan H. · Journal of Orthopaedic Translation. 2016;5:9–15.
Intrathecal infusion of hydrogen-rich normal saline attenuates neuropathic pain via inhibition of activation of spinal astrocytes and microglia in rats
Ge Y et al. · PLoS One. 2014;9(5):e97436.
Hydrogen water consumption prevents osteopenia in ovariectomized rats
Guo JD, Li L, Shi YM, Wang HD, Hou SX. · British Journal of Pharmacology. 2013;168(6):1412-1420.
Hydrogen-rich saline attenuated neuropathic pain by reducing oxidative stress
Chen Q, Chen P, Zhou S, Yan X, Zhang J, Sun X, Yuan H, Yu W. · Can J Neurol Sci. 2013;40(6):857–863.
Effects of hydrogen-rich water on oxidative stress in rats with disuse muscle atrophy
Nagayama T et al. · J Physiol Anthropol. 2011;30(5):195–201.