Hydrogen-Rich Water Potentiates Cannabinoid- and Gabapentinoid-Induced Analgesia in Neuropathic Pain
Tort NA, Negrini-Ferrari SE, Pol O. · International journal of molecular sciences. 2025;26(24):12155.
Study at a glance
Preclinical
mice, tissue, mouse, tissues used to study musculoskeletal and pain research.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 0.3 mM. · H₂-related quantities reported in the intervention passages: 0.3 mM. Values are not combined across different experimental arms.
Multiple article-specific time points; see the linked full methods.
Article-reported result excerpt (24 words maximum): “Thus, a significant reduced threshold of the ipsilateral hind paw withdrawal to von Frey filament stimulation, a reduced withdrawal threshold of the ipsilateral hind…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
What kind of evidence is this?
Preclinical
Randomized controlled study
Musculoskeletal and pain research
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
mice, tissue, mouse, tissues used to study musculoskeletal and pain research.
Preclinical study; the full text reports 372 mice, with group/assay counts including n=6, n=3.
Multiple article-specific time points; see the linked full methods.
Full text reports H₂ dissolved in drinking water. Detected intervention quantities or schedules: 0.3 mM.
H₂ dissolved in drinking water — H₂ only unless the full text explicitly reports oxygen co-delivery.
H₂-related quantities reported in the intervention passages: 0.3 mM. Values are not combined across different experimental arms.
Control or comparison condition reported in the full article; see the linked methods for arm-specific details.
Outcomes and reported result
clinical symptoms or functional scores, inflammation and cytokines, oxidative-stress and antioxidant markers, apoptosis or cell injury, histology or tissue damage, metabolic laboratory measures
Article-reported result excerpt (24 words maximum): “Thus, a significant reduced threshold of the ipsilateral hind paw withdrawal to von Frey filament stimulation, a reduced withdrawal threshold of the ipsilateral hind…” This excerpt is not a complete result summary; consult the linked full text for all positive and null findings.
The complete machine-readable article was checked for source identity, methods, intervention quantities, results, tables, funding and conflict declarations. This public record is based on the full article.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Preclinical evidence only; findings do not establish a treatment effect in people. Funding or grant information is reported in the full article. The article declares no conflicts of interest.
Applies to the reported animal, cell or tissue model, not directly to patients.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 41465581 · DOI: 10.3390/ijms262412155
A free full article is available through PubMed Central.
Official PubMed/PMC full article; source identity, intervention data and declarations re-audited 25 August 2026.
25 August 2026
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