Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome
Song G et al. · J Lipid Res. 2013;54(7):1884–1893.
Study at a glance
Human
Adults with one or more metabolic-risk features
Hydrogen-rich water, 450–500 mL twice daily; 0.9–1.0 L/day · 0.2–0.25 mM dissolved H₂; pH 7.8–8.2; prepared with a magnesium-based product.
10 weeks
Total and LDL cholesterol decreased from baseline; HDL cholesterol, glucose and most triglyceride results did not change. Several ex-vivo lipoprotein-function measures improved, while TNF-α and IL-6 did not.
Uncontrolled 20-person study with many laboratory and ex-vivo outcomes; lifestyle change and regression to the mean cannot be separated from an intervention effect. The article itself says a solid conclusion cannot be drawn.
What kind of evidence is this?
Human
Uncontrolled before-and-after study
Metabolic and lipid health
H₂-rich water
Information not yet classified
Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.
Methods
Adults with one or more metabolic-risk features
20 participants
10 weeks
Hydrogen-rich water, 450–500 mL twice daily; 0.9–1.0 L/day
H₂ dissolved in water — H₂ only, not Brown’s gas.
0.2–0.25 mM dissolved H₂; pH 7.8–8.2; prepared with a magnesium-based product.
No concurrent placebo or untreated comparator
Outcomes and reported result
Serum lipids, oxidative and inflammatory biomarkers, and ex-vivo LDL/HDL functional assays
Total and LDL cholesterol decreased from baseline; HDL cholesterol, glucose and most triglyceride results did not change. Several ex-vivo lipoprotein-function measures improved, while TNF-α and IL-6 did not.
Methods and main results checked in the free full text; independent appraisal remains incomplete.
A reported association, difference or mechanism is not automatically a clinical benefit.
Limitations and applicability
Uncontrolled 20-person study with many laboratory and ex-vivo outcomes; lifestyle change and regression to the mean cannot be separated from an intervention effect. The article itself says a solid conclusion cannot be drawn.
Adults with the metabolic-risk features used by this study.
No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.
Sources and record status
PMID: 23610159 · DOI: 10.1194/jlr.M036640
Open-access full text is available through PMC.
Free full text on PMC; bibliographic identifiers cross-checked in PubMed.
10 August 2026
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