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Hydrogenology
Source-linked study record

Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans

Kato S, Takada Y, Miwa N. · Journal of Thermal Biology. 2021;95:102805.

HumanOther formsPublished 2021Source checked
Study record, not medical adviceThis record reports what the source states. It is not medical advice and does not establish that molecular hydrogen is effective, safe or appropriate for any person.
Quick summary

Study at a glance

In a 24-person bath study, some skin areas stayed warmer for an hour after hydrogen-containing baths. An axillary/core-temperature benefit was not shown. The experiment did not test treatment of illness or measure whole-body blood flow.

Source data warningCapillary analysis selected sixteen participants, while Figure 10 also gives an ambiguous n = 10. These denominators are not interchangeable. Specific endpoints do not establish a uniform or monotonic concentration response.
Evidence type

Human

Population or model

Twenty-four healthy adults aged 24–58; eleven men and thirteen women. A selected subgroup had clearly visible capillaries.

Intervention and dose

LitaLife Ver.2 (WCJ, Osaka) electrolyzed 160 L tap water at 41°C for thirty or 120 minutes before a ten-minute neck-deep bath. Conditions at least seven days apart. Separate hand immersion used 15 L at 40°C for ten minutes. · After preparation, approximately 185 or 548 µg/L H₂ (not mg/L); ORP −91 or −167 mV. Thirty/120 minutes are water-preparation times, not body-exposure durations.

Duration

Ten-minute body bath; thermography before, immediately after, thirty and sixty minutes later. Separate ten-minute hand immersion, capillary measurements before and thirty/sixty minutes later.

Reported result

Whole-body mean surface-temperature increases at sixty minutes were 0.65°C after thirty-minute preparation, 0.90°C after 120-minute preparation and 0.12°C control. Abdominal increases at thirty/sixty minutes: 1.82/1.96°C, 1.17/1.12°C and 0.44/0.66°C respectively. Some arm, upper-leg, hand and foot comparisons favored hydrogen. Selected capillary subgroup diameter increases at thirty/sixty minutes: 1.03/1.12 µm, 1.93/1.03 µm, versus −0.14/−0.59 µm control; authors report differences and 14.7–27.6% changes. Axillary temperature was nonsignificant; head/lower-leg heat retention was scarce or mixed. Higher concentration did not consistently yield greater regional effects. Body-composition correlations were not clearly stronger than control; basal-metabolic-rate correlation was negligible.

Main limitation

Small healthy sample, short surrogate outcomes, unstated randomized order, selected subgroup, many region/time comparisons without stated multiplicity adjustment. Diameter is not direct whole-body blood flow. Unequal bathrobe coverage and electrolysis-related changes in water chemistry complicate interpretation; proposed mechanisms remain speculative.

Evidence and classification

What kind of evidence is this?

Evidence type

Human

Reported design

Within-person three-condition bath comparison, described as double-blind handled with dummy apparatus and coded/shuffled analysis. Randomized condition order not reported.

Research topic

Musculoskeletal and pain research

Administration form

Other forms

Information not yet classified

Some editorial classification fields are still pending. The source-reported outcomes and result are shown below; Hydrogenology does not infer a positive or negative signal from prose automatically.

Reported in the source

Methods

Population or model

Twenty-four healthy adults aged 24–58; eleven men and thirteen women. A selected subgroup had clearly visible capillaries.

Sample

24 in thermography. Capillary subgroup sixteen of 24; Figure 10 also labels n = 10, apparently measurement points but ambiguous. These are not separate groups of 24 or ten independent capillary patients.

Duration

Ten-minute body bath; thermography before, immediately after, thirty and sixty minutes later. Separate ten-minute hand immersion, capillary measurements before and thirty/sixty minutes later.

Intervention

LitaLife Ver.2 (WCJ, Osaka) electrolyzed 160 L tap water at 41°C for thirty or 120 minutes before a ten-minute neck-deep bath. Conditions at least seven days apart. Separate hand immersion used 15 L at 40°C for ten minutes.

Hydrogen form

Hydrogen-containing topical water

Dose or H₂ specification

After preparation, approximately 185 or 548 µg/L H₂ (not mg/L); ORP −91 or −167 mV. Thirty/120 minutes are water-preparation times, not body-exposure durations.

Comparator

Same 41°C tap-water bath for ten minutes, approximately 0.8–1 µg/L H₂, ORP +479 mV; dummy apparatus.

Reported, not endorsed

Outcomes and reported result

Outcomes measured

Regional surface thermography, axillary temperature and selected finger-capillary loop diameters; correlations with body composition.

Reported result

Whole-body mean surface-temperature increases at sixty minutes were 0.65°C after thirty-minute preparation, 0.90°C after 120-minute preparation and 0.12°C control. Abdominal increases at thirty/sixty minutes: 1.82/1.96°C, 1.17/1.12°C and 0.44/0.66°C respectively. Some arm, upper-leg, hand and foot comparisons favored hydrogen. Selected capillary subgroup diameter increases at thirty/sixty minutes: 1.03/1.12 µm, 1.93/1.03 µm, versus −0.14/−0.59 µm control; authors report differences and 14.7–27.6% changes. Axillary temperature was nonsignificant; head/lower-leg heat retention was scarce or mixed. Higher concentration did not consistently yield greater regional effects. Body-composition correlations were not clearly stronger than control; basal-metabolic-rate correlation was negligible.

Extraction completeness

Main-text methods, results, limitations and declarations were reviewed. Source versions, missing information and conflicting findings are stated in this record.

Reported adverse events

No systematic adverse-event assessment or counts stated; safety is not established by absent reporting.

A reported association, difference or mechanism is not automatically a clinical benefit.

Interpretation limits

Limitations and applicability

Main methodological cautions

Small healthy sample, short surrogate outcomes, unstated randomized order, selected subgroup, many region/time comparisons without stated multiplicity adjustment. Diameter is not direct whole-body blood flow. Unequal bathrobe coverage and electrolysis-related changes in water chemistry complicate interpretation; proposed mechanisms remain speculative.

Applies directly to

Limited to the population/model and protocol described above. These findings do not provide a treatment, concentration or device recommendation.

Funding and support

Japanese Center for Anti-Aging Medical Sciences grant 17T01 to Shinya Kato.

Conflicts of interest

Authors declare no conflicts. The commercial device is identified; hosting by a retailer is not independent validation.

No single-study GRADE certainty rating is assigned. Read how records and evidence assessments are prepared.

Sources and status

Sources and record status

Identifiers

PMID: 33454037 · DOI: 10.1016/j.jtherbio.2020.102805

Publisher access

Complete final eleven-page Journal of Thermal Biology article, 95 (2021), 102805; online 5 December 2020. The copy is on a CDN linked by the research page of a Russian hydrogen-equipment retailer.

Editorial verification

AI-assisted editorial review of the available main full text, 29 October 2026. No independent clinical or statistical assessment has been performed.

Source sections checked

All eleven pages: Methods 2.1–2.5.1; Table 1; Results 3.1–3.4; Figures 1–10; Discussion; funding; conflicts and references.

Extraction basis

AI-assisted editorial review of the available main full text, 29 October 2026. Complete final eleven-page Journal of Thermal Biology article, 95 (2021), 102805; online 5 December 2020. The copy is on a CDN linked by the research page of a Russian hydrogen-equipment retailer.

Registry / related-source limitations

Ethics JCAAMS 17T01; no trial-registration identifier reported.

Last reviewed

29 October 2026

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