Independent research library

Molecular hydrogen (H2) research library

Explore 665 full-text-checked human, animal and laboratory studies on molecular hydrogen (H2), with methods, reported findings and limitations clearly separated.

665full-text-checked records

193human studies

472animal and laboratory records

How to interpret this libraryA study record reports what a source states and what was extracted from the complete available text. Inclusion is not proof of effectiveness, safety or clinical suitability. Human and preclinical evidence, clinical outcomes and biomarkers remain distinct.

665 matching records · page 2 of 28

PreclinicalH₂-rich water2026

Long-Term Consumption of Hydrogen-Rich Water Mitigates Oxidative Stress, Hepatic Inflammation, and Apoptosis in Rats with LPS-Induced Chronic Liver Injury

Zhang L, Wang H, Mai Y, He Q, Liu T, Zhang N, Zhang J. · Antioxidants (Basel, Switzerland). 2026;15(2):260.

Read the source-checked record →Original source ↗

HumanInhaled H₂2026

Long-term survival in patients with primary malignant brain tumors after postoperative home hydrogen inhalation: Three case reports

Xu KC, Kong XF, Qian W, Liang B, Li DG, Korpan NN. · World Journal of Clinical Cases. 2026;14(20):121466.

Read the source-checked record →Original source ↗

PreclinicalOther forms2026

Magnesium silicate nanosheets enable sustained hydrogen release to attenuate secondary brain injury following intracerebral hemorrhage

Ma CS, Han B, Guo JR, Guo JF, Shi CK, Liu YX, Yi WJ, Zhang LY, Deng AJ, Wang YS, He MT. · Journal of translational medicine. 2026;24(1):352.

Read the source-checked record →Original source ↗

PreclinicalH₂-rich water2026

Mechanism by which hydrogen-rich water mitigates exercise-induced fatigue: activation of the immunoresponsive gene 1-itaconate/nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway

Zhang Y, Ying Y, Zu X, Ding L, Shi X, Wang J, Li X, Li C, Zhou Q, Shen H, Li H, Lu H, Cheng J. · Medical gas research. 2026;16(1):26-32.

Read the source-checked record →Original source ↗

PreclinicalOther forms2026

Mitigation of Ischemia-Reperfusion Injury and Improvement in Overall Graft Viability by Hypothermic Pulsatile Perfusion with Molecular Hydrogen Is Associated with Trx-1/HO-1 Activation in a Non-Survival Ex Vivo Swine Model of Donation-After-Circulatory-Death Kidney Preservation and Transplantation

Dugbartey GJ, England C, Ortas TS, Richard-Mohamed M, Jiang L, Shamma T, Igbokwe M, Bozaci A, Oyarzun JG, Seok D, Zainul SA, Harrow L, Freeman M, Lindo-Anu R, Ruthirakanthan A, Alfaifi A, Wang J, McLeod P, Haig A, Bonham C, Sener A. · International journal of molecular sciences. 2026;27(11):4931.

Read the source-checked record →Original source ↗

PreclinicalInhaled H₂2026

Molecular Hydrogen Attenuates Chronic Inflammation and Delays the Onset of Ultraviolet B-Induced Skin Carcinogenesis in Mice

Hori F et al. · Int J Mol Sci. 2026;27(2):635.

Read the source-checked record →Original source ↗

HumanOther forms2026

Molecular hydrogen is associated with immunophenotypic modulation and changes in T-cell exhaustion markers in refractory primary Sjögren’s syndrome-associated interstitial lung disease: A case report

Hsu WH, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. · SAGE open medical case reports. 2026;14:2050313X261454858.

Read the source-checked record →Original source ↗

PreclinicalInhaled H₂2026

Molecular Hydrogen Modulates the Baroreflex Activity and Reduces the Vascular Adrenoreceptor Sensitivity to Phenylephrine and Lung Inflammation in Rats with Pulmonary Hypertension

Artemieva M, Kozaeva L, Kuropatkina T, Gufranov K, Atiakshin D, Medvedeva N, Medvedev O. · Biomedicines. 2026;14(3):494.

Read the source-checked record →Original source ↗

PreclinicalH₂-rich water2026

Molecular Hydrogen Reverses Nociplastic Pain and Depressive-like Behaviors via Region- and Sex-Dependent Central Mechanisms

Negrini-Ferrari SE et al. · Int J Mol Sci. 2026;27(7):3051.

Read the source-checked record →Original source ↗

PreclinicalOther forms2026

Molecular hydrogen triggers TRPC4-TRPC4AP-dependent reversible calcium transients via extracellular influx

Zhao P, Li H, Cai Z, Zhang X, Wen X, Liu Z, Jiang S, Jiang X, Wang J, Dang Z, Liu M, Xie F, Ma X. · Theranostics. 2026;16(9):4843-4864.

Read the source-checked record →Original source ↗

PreclinicalOther forms2026

Neuroprotective Effects of Molecular Hydrogen via Oxidative Stress and Neuroinflammation Regulation in a 5xFAD Mouse Model

Mo C, Bajgai J, Rahman MH, Ma H, Pham TT, Zhang H, Cao B, Jeong ES, Kim CS, Lee KJ. · Antioxidants (Basel, Switzerland). 2026;15(3):404.

Read the source-checked record →Original source ↗

PreclinicalOther forms2026

Precise Aβ clearance and antioxidant therapy in Alzheimer’s disease via photoacoustic imaging-guided palladium hydride nanosheet-mediated photothermal treatment

Yu L, Zhao M, Zhang W, Lv Z, Zhao K, Li H, Qi Y, Peng X, Zheng Z, Zhang W. · BMC neuroscience. 2026;27(1):8.

Read the source-checked record →Original source ↗

HumanH₂-rich water2026

Redox Water Consumption Attenuates Exercise-Induced Inflammation and Oxidative Stress in Physically Active Adults: A Randomized Controlled Trial

Stolecka-Warzecha A et al. · Nutrients. 2026;18(4):694.

Read the source-checked record →Original source ↗

HumanOther forms2026

Rhupus Syndrome With Multiple Drug Intolerances Managed by Reduced-dose Rituximab and Adjunctive Molecular Hydrogen Therapy: A Case Report

Tsai HL, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. · In vivo (Athens, Greece). 2026;40(1):561-570.

Read the source-checked record →Original source ↗

HumanOther forms2026

Safety and efficacy of a novel fecal microbiota transplantation method using hydrogen nanobubble water without antibiotics or bowel cleansing in children with autism spectrum disorder: an open-label, single-arm study demonstrating improvements in core and comorbidity symptoms.

Shirotani M, Shimizu S, Kitamura K, Mikawa Y, Haruna R, Kawai Y, Koide S, Mohri I, Matsuzaki H, Tsuchiya KJ, Tanaka Y, Katayama T. · Frontiers in Pediatrics. 2026;14:1767346.

Read the source-checked record →Original source ↗

PreclinicalOther forms2026

Silicon-based agent mitigates fatty liver formation in a CDAHFD60-induced MASH mouse model by enhancing hepatic function.

Koyama Y, Kobayashi Y, Hirota I, Kobayashi H, Shimada S. · Biochemistry and Biophysics Reports. 2026;46:102552.

Read the source-checked record →Original source ↗

HumanInhaled H₂2026

Sixty-minute inhalation of molecular hydrogen decreases blood oxygen saturation but does not alter autonomic cardiac regulation at rest in healthy females

Grepl P et al. · Can J Physiol Pharmacol. 2026;104:1–9.

Read the source-checked record →Original source ↗

HumanInhaled H₂2026

The combined use of inhaled nitric oxide and molecular hydrogen in patients with post-COVID-19 syndrome

Pozdnyakova DD, Baranova IA, Selemir VD, Medvedev OS, Chuchalin AG. · Ter Arkh. 2026;98(3):147–153.

Read the source-checked record →Original source ↗

HumanInhaled H₂2026

The effect of stabilized hydrogen inhalation on clinical and functional parameters in patients with chronic obstructive pulmonary disease

Antipushina DN, Smirnova MI, Gorshkov AYu, Strelkova AV, Ryzhakova LN, Emelyanov AV, Voinova SN, Ignatikova EN, Koshelyaevskaya YaN, Gufranov KF, Drapkina OM. · Russian Journal of Preventive Medicine. 2026;29(6):58–67.

Read the source-checked record →Original source ↗

HumanInhaled H₂2026

The results of stabilised hydrogen inhalations in patients with asthma

Smirnova MI, Antipushina DN, Gorshkov AYu, Strelkova AV, Ryzhakova LN, Emelyanov AV, Voinova SN, Ignatikova EN, Koshelyaevskaya YaN, Gufranov KF, Drapkina OM. · Russian Journal of Preventive Medicine. 2026;29(4):83–90.

Read the source-checked record →Original source ↗

HumanOther forms2025

A Case Report of Adjuvant Molecular Hydrogen Therapy in Refractory Rheumatoid Arthritis With Atlantoaxial Subluxation.

Ren YC, Lu JW, Ho YJ, Lui SW, Hsieh TY, Wang KY, Liu FC. · In Vivo. 2025;39:14166.

Read the source-checked record →Original source ↗

HumanOther forms2025

Adjunctive molecular hydrogen therapy for refractory malar rash in systemic lupus erythematosus: A case report with immunological insights.

Hsu NS, Lu JW, Liu HC, Ho YJ, Wang KY, Liu FC. · SAGE Open Medical Case Reports. 2025;13:2050313X251372755.

Read the source-checked record →Original source ↗

HumanInhaled H₂2025

Alleviation of exercise-induced injury by hydrogen inhalation via the reduction of oxidative stress and inflammation in athletes

Zhang X, Lu X, Li F, Gu H, Cheng X, Tang J, Zhang X, Jiang J, Feng L, Li X. · Journal of thoracic disease. 2025;17(8):6151-6162.

Read the source-checked record →Original source ↗

PreclinicalInhaled H₂2025

Application of Molecular Hydrogen in Early Heart Failure Development: Modulation of Microcirculation, Metabolism, Oxidative Stress, and Myocardial Status

Deryugina AV, Danilova DA, Polozova AV. · Antioxidants (Basel, Switzerland). 2025;14(12):1418.

Read the source-checked record →Original source ↗