Independent research library

Molecular hydrogen (H2) research library

Explore 665 full-text-checked human, animal and laboratory studies on molecular hydrogen (H2), with methods, reported findings and limitations clearly separated.

665full-text-checked records

193human studies

472animal and laboratory records

How to interpret this libraryA study record reports what a source states and what was extracted from the complete available text. Inclusion is not proof of effectiveness, safety or clinical suitability. Human and preclinical evidence, clinical outcomes and biomarkers remain distinct.

665 matching records · page 3 of 28

HumanInhaled H₂2025

Clinical Efficacy of Hydrogen Therapy on Acute Radiation Enteritis and Inflammatory Response in Patients with Cervical Cancer Undergoing Concurrent Chemoradiation Therapy

Liu B, Bao Y, Ma J, Wang X, Feng Y. · Advances in radiation oncology. 2025;10(11):101879.

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HumanOther forms2025

Comparison of the Antimicrobial Effect of Hydrogen Water and Chlorhexidine Mouth rinse in Toothbrush Disinfection Among Dental Students.

Vaishnavi C, Elangovan GP, Thirumal M, Prashanth SV, Deepika D, Pragathi TG. · Journal of Pharmacy and Bioallied Sciences. 2025;17:1565-24.

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HumanInhaled H₂2025

Complementary Therapies of Diabetic Peripheral Neuropathy and Intermittent Claudication

Ng SY. · 2025.

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PreclinicalOther forms2025

Coral calcium hydride promotes peripheral mitochondrial division and reduces AT-II cells damage in ARDS via activation of the Trx2/Myo19/Drp1 pathway

Li Q, Ang Y, Zhou QQ, Shi M, Chen W, Wang Y, Yu P, Wan B, Yu W, Jiang L, Shi Y, Lin Z, Song S, Duan M, Long Y, Wang Q, Liu W, Bao H. · Journal of pharmaceutical analysis. 2025;15(3):101039.

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PreclinicalH₂-rich water2025

Degradation products of magnesium implant synergistically enhance bone regeneration: Unraveling the roles of hydrogen gas and alkaline environment

An Y, Zhang H, Zhang S, Zhang Y, Zheng L, Chen X, Tong W, Xu J, Qin L. · Bioactive materials. 2025;46:331-346.

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PreclinicalInhaled H₂2025

DGKζ in Glycerophospholipid Metabolism Regulates the DAG and PA Balance and Interacts With PTEN to Alleviate Brain Damage in Septic Mice With Hydrogen Inhalation: A Comparative Metabolomic and Phosphoproteomic Analysis

Bai Y, Li Z, Yan D, Jiang Y, Dong B, Yu Y. · Brain and behavior. 2025;15(8):e70761.

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PreclinicalOther forms2025

Dietary addition of magnesium hydride nanoparticles: a breakthrough in combating high-fat diet-induced chronic kidney disease.

Lu H, Chen W, Ying Y, Gu D, Li R, Li X, Cheng J, Sun X, Zhang Y, Liu W, Shen H. · Medical Gas Research. 2025;15:90.

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HumanInhaled H₂2025

Effect of hydrogen inhalation on functional characteristics and intestinal gas biomarkers in wrestlers during physical exercise

Medvedev OS, Uzhakov AA, Konnova OL, Povarova OV. · Sports Medicine: Research and Practice. 2025;15(2):20–30.

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HumanH₂-rich water2025

Effects of 12-Week Hydrogen-Rich Water Consumption on Body Composition and Metabolic Biomarkers in Adults with Metabolic Syndrome Stratified by Breath Hydrogen Levels: A Randomized Controlled Trial

Todorović N, Nedeljkovic D, Korovljev D, et al. · Current Topics in Nutraceutical Research. 2025;23(2):29–38.

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PreclinicalH₂-rich water2025

Effects of hydrogen-rich water on growth, redox homeostasis and hormonal, histological and immune systems in rats exposed to high cage density stress

Kuru BB, Makav M, Kuru M, Aras SY, Sarı EK, Bulut M, Alwazeer D, Bektaşoğlu F, Ölmez M, Kırmızıbayrak T, LeBaron TW. · Veterinary Medicine and Science. 2025;11(2):e70305.

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PreclinicalInhaled H₂2025

Efficacy of a hydrogen–oxygen generator in treating cigarette smoke–induced chronic obstructive pulmonary disease in rats

Huang WT, Cheng TJ, Huang LH, Hou YT. · Current Research in Toxicology. 2025;8:100214.

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HumanOther forms2025

Efficacy of Oral Intake of Hydrogen-Rich Jelly Intake on Gingival Inflammation: A Double-Blind, Placebo-Controlled and Exploratory Randomized Clinical Trial

Maruyama T, Takayama E, Tokuno S, Morita M, Ekuni D. · Healthcare (Basel, Switzerland). 2025;13(5):577.

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HumanInhaled H₂2025

Efficiency and safety of the integrated use of medical gases thermal heliox, nitric oxide and molecular hydrogen in patients with exacerbation of chronic obstructive pulmonary disease complicated by hypoxemic, hypercapnic respiratory failure and secondary pulmonary arterial hypertension in the post-COVID period

Shogenova LV. · Ter Arkh. 2025;97(3):242–249.

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HumanInhaled H₂2025

Fatigue disappearance in hemodialysis patients by dual approach with hydrogen gas inhalation and hydrogen-enriched dialysate: two case reports

Nakazawa R, Nagami S, Nozaki H, Yataka M, Akiyama K, Uchino T, Azuma N. · Medical Gas Research. 2025;15(1):59–61.

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PreclinicalH₂-rich water2025

Four-dimensional data independent acquisition proteomics and metabolomics reveal mechanisms of hydrogen-rich water at Zusanli (ST36) point against triple-negative breast cancer in mice

Liu J, Mo Q, Lei G, Jia Y, Li A, Jia C, Pan L. · Journal of Traditional Chinese Medicine. 2025.

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HumanOther forms2025

Hemodialysis employing molecular hydrogen (H₂) enriched dialysis solution may improve dialysis related fatigue through impact on energy metabolism

Nakayama M, Watanabe K, Sato E, et al. · Scientific Reports. 2025;15:5039.

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PreclinicalOther forms2025

Hydrogen gas (H_2) delivered by intraperitoneal injection alleviated methionine- and choline-deficient diet-induced metabolic dysfunction–associated steatotic liver disease in mice via inhibiting GSDMD- and GSDME-mediated pyroptosis

Chen Y, Wang K, Guo W, Lu C, Suo W, Li Q, Deng Y, Chen X, Dai M, Zhang X, Xu J, Su W, Yang S, Yang H, Yan F, Liu H, Zhang Y. · Frontiers in pharmacology. 2025;16:1575106.

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PreclinicalOther forms2025

Hydrogen Gas Attenuates Toxic Metabolites and Oxidative Stress-Mediated Signaling to Inhibit Neurodegeneration and Enhance Memory in Alzheimer’s Disease Models

Abdul-Nasir S, Chau CT, Nguyen TT, Bajgai J, Rahman MH, Hwang-Un K, You IS, Kim CS, Seo BA, Lee KJ. · International journal of molecular sciences. 2025;26(14):6922.

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PreclinicalInhaled H₂2025

Hydrogen gas inhalation ameliorates glomerular enlargement after hypoxic-ischemic insult in asphyxiated piglet model

Iwaki T, Nakamura S, Wakabayashi T, Nakao Y, Htun Y, Tsuchiya T, Mitsuie T, Koyano K, Morimoto A, Fuke N, Yokota T, Kondo S, Konishi Y, Miki T, Ueno M, Iwase T, Kusaka T. · Scientific reports. 2025;15(1):1677.

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HumanInhaled H₂2025

Hydrogen Gas Inhalation Improved Intestinal Microbiota in Ulcerative Colitis: A Randomised Double-Blind Placebo-Controlled Trial

Maruyama T et al. · Biomedicines. 2025;13(8):1799.

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PreclinicalOther forms2025

Hydrogen gas mitigates acute hypoxia-induced oxidative and inflammatory brain injuries in medaka (Oryzias latipes)

Sato E, Shimamura N, Saiki C, Sunada K, Miwa N, Xiao L. · Antioxidants. 2025;14(9):1130.

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PreclinicalOther forms2025

Hydrogen gas therapy: A promising approach for sepsis management post-burn injury by modulating inflammation, oxidative stress, and wound healing

Yu P, Hong N, Wang G, Chen S, Zhao Z. · CytoJournal. 2025;22:46.

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PreclinicalOther forms2025

Hydrogen inhalation ameliorates lung inflammation in mice with asthma

Li H et al. · Eur J Med Res. 2025;30:1024.

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PreclinicalInhaled H₂2025

Hydrogen inhalation and intrathecal magnesium sulfate ameliorate ischemia by suppressing cortical spreading depolarization in a rat subarachnoid hemorrhage model

Yoshiura T, Kawauchi S, Nishida S, Sato S, Hagita D, Endo A, Nakagawa M, Fujii T, Otsuka Y, Mishima Y, Fujii K, Takeuchi S, Tomiyama A, Toyooka T, Sato S, Wada K. · Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2025;22(5):e00617.

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