Performance of unmodified mechanical ventilators with 2% hydrogen gas mixtures
Mancebo JG, Sack K, Nguyen R, Peng Y, Sosa S, Anders M, Roddy DJ, Kheir JN. · Respiratory Care. 2025;70(4):377–383.
Other administration forms research
Browse 260 source-checked molecular hydrogen records classified as other administration forms, with human and preclinical evidence separated.
260source-checked study records
57human studies
203animal and laboratory records
No treatment conclusion is impliedAdministration routes, concentrations, doses and treatment schedules vary and must not be treated as interchangeable. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.
Pharmacokinetics of Hydrogen During Hydrogen-Saturated Saline Infusion in Pigs
Shibuya M, Fujinaka M, Yonezawa M, Nishimura N, Uchinoumi H, Sunahara H, Tani K, Kobayashi E, Sano M. · Biomedicines. 2025;13(1):234.
Precision Assessment of Anti-NMDA Receptor Encephalitis: A Case Report on Integrating Clinical Course, Immunophenotyping, and Comprehensive Symptomatology in a Pediatric Patient With Adjunctive Hydrogen Therapy.
Lin SC, Lu JW, Lin TC, Sung YF, Ho YJ, Wang FM, Lui SW, Hsieh TY, Wang KY, Liu FC. · In Vivo. 2025;39:13858.
Preventive and Therapeutic Effects of Hydrogen-Generating Si-Based Agent on Pressure Ulcers in Mice
Otani N, Oue T, Kobayashi Y, Kobayashi H, Tomita K, Kubo T. · Biomedicines. 2025;13(10):2475.
Protective Effects of Hydrogen Treatment Against High Glucose-Induced Oxidative Stress and Apoptosis via Inhibition of the AGEs/RAGE/NF-κB Signaling Pathway in Skin Cells
Yu P, Hong N, Wu Q, Zhao Z. · Endocrine, metabolic & immune disorders drug targets. 2025;25(14):1177-1190.
Protective Effects of Hydrogen-Rich Saline Against Hemorrhagic Shock in Rats via an Endothelial Glycocalyx Pathway
Kimura A, Suehiro K, Yamada T, Shinta Y, Juri T, Fujimoto Y, Hirano S, Mori T. · Biomedicines. 2025;13(4):833.
Research on the inhibitory effect of hydrogen gas on ovarian cancer and potential mechanisms
Yin M, Liu M, Zhang C, Peng L, Guo Z, Hao Y, Wang Y, Zhang X, Shi Q, Ren X, Li H, Zhang L. · European journal of medical research. 2025;30(1):874.
Silicon-Based Agent Attenuates Age-Related Spermatogenesis Disorder.
Kuribayashi S, Fukuhara S, Kitakaze H, Tsujimura G, Imanaka T, Ueda N, Takezawa K, Kobayashi H, Imamura R, Nonomura N. · International Journal of Urology. 2025.
Spontaneous hydrogen-releasing nanoenzyme alleviates osteoarthritis via oxidative stress reduction and mitochondrial dysfunction reversal
Wang Q, Zhang M, Jiang W, Li D, Qi B, Shi S, Shi S, Yi C. · Journal of nanobiotechnology. 2025;23(1):662.
Sustained-release photothermal microneedles for postoperative incisional analgesia and wound healing via hydrogen therapy
Zhang A, Jiang X, Xiong B, Chen J, Liu X, Wang S, Li B, Peng M, Li W. · Advanced Science. 2025;12(35):e03698.
The augment effects of magnesium hydride on the lipid lowering effect of atorvastatin: an in vivo and in vitro investigation.
Chen W, Zhang Y, Miao G, Ying Y, Ren Z, Sun X, Cai J, Shen H, Lu H. · Medical Gas Research. 2025;15:47.
Topically Applied Molecular Hydrogen Normalizes Skin Parameters Associated with Oxidative Stress: A Pilot Study
Debkowska N et al. · Antioxidants (Basel). 2025;14(6):729.
A novel antioxidant, hydrogen-rich coral calcium, alters gut microbiome and bile acid synthesis to improve methionine-and-choline-deficient diet-induced non-alcoholic fatty liver disease
Wu HT, Tsai CS, Chao TH, Ou HY, Tsai LM. · Antioxidants (Basel). 2024;13(6):746.
Clinical Observation of Hydrogen-Rich Saline for Nasal Irrigation After Surgery for Chronic sinusitis:A Randomized, Double-Blind, Controlled Trial
Jin L, Fan K, Yao C, Chang Y, Wang Y, Lu J, Yu S. · Journal of inflammation research. 2024;17:7361-7372.
Evaluation of the effect of enriched hydrogen saline solution on distant organ (lung) damage in skeletal muscle ischemia reperfusion in rats
Özer A, Erel S, Küçük A, Demirtaş H, Sezen ŞC, Boyunağa H, Oktar GL, Arslan M. · 2024.
Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas.
McCurry MD, D'Agostino GD, Walsh JT, Bisanz JE, Zalosnik I, Dong X, Morris DJ, Korzenik JR, Edlow AG, Balskus EP, Turnbaugh PJ, Huh JR, Devlin AS. · Cell. 2024;187:2717-2732.
Hydrogen gas improves proliferation and mitochondrial activity of human adipose-derived stem cells after cryopreservation
Kimura K, Tabata Y. · Regenerative therapy. 2024;26:571-577.
Hydrogen Therapy Reverses Cancer‐Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti‐Tumor Immunity
Meng X, Liu Z, Deng L, Yang Y, Zhu Y, Sun X, Hao Y, He Y, Fu J. · Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024;11(28):e2401269.
Hydrogen treatment reduces electroencephalographic activity and neuronal death in rats with refractory status epilepticus by inhibiting membrane NR2B phosphorylation and oxidative stress
Jia R, Zhu G, Zhao R, Li T, Jiang W, Cui X. · The Journal of international medical research. 2024;52(3):3000605241235589.
Hydrogen-rich alkaline water supplementation restores a healthy state and redox balance in H₂O₂-treated mice
Mizzoni D, Logozzi M, Di Raimo R, Spada M, Fais S. · Int J Mol Sci. 2024;25(12):6736.
Hydrogen-rich solution alleviates acute radiation pneumonitis by regulating oxidative stress and macrophages polarization
Yin Z, Xu W, Ling J, Ma L, Zhang H, Wang P. · Journal of radiation research. 2024;65(3):291-302.
Inhalation of hydrogen gas protects against mitomycin-induced pulmonary veno-occlusive disease
Zhang C et al. · Respir Res. 2024;25:281.
Molecular hydrogen and extracorporeal gas exchange: a match made in heaven? An in vitro pilot study
Mouzakis FL, Hima F, Kashefi A, Greven J, Rink L, van der Vorst EPC, Jankowski J, Mottaghy K, Spillner J. · Biomedicines. 2024;12(8):1883.
Molecular Hydrogen as a Promising Therapy Could Be Linked With Increased Resting Treg Cells or Decreased Fas+ T Cell Subsets in a IgG4-PF-ILD Patient: A Case Report
Lui SW, Lu JW, Ho YJ, Tang SE, Ko KH, Hsieh TY, Liu FC. · In Vivo. 2024;38(3):1512-1518.