Hydrogen-Rich Water Intake Accelerates Oral Palatal Wound Healing via Activation of the Nrf2/Antioxidant Defense Pathways in a Rat Model
Tamaki N, Orihuela-Campos RC, Fukui M, Ito HO. · Oxidative medicine and cellular longevity. 2016;2016:5679040.
Hydrogen-rich water research
Browse 220 source-checked molecular hydrogen records classified as hydrogen-rich water, with human and preclinical evidence separated.
220full-text-checked records
73human studies
147animal and laboratory records
No treatment conclusion is impliedAdministration routes, concentrations, doses and treatment schedules vary and must not be treated as interchangeable. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.
Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism
Kamimura N, Ichimiya H, Iuchi K, Ohta S. · NPJ Aging and Mechanisms of Disease. 2016;2:16008.
Molecular hydrogen suppresses activated Wnt/β-catenin signaling
Lin Y, Ohkawara B, Ito M, Misawa N, Miyamoto K, Takegami Y, Masuda A, Toyokuni S, Ohno K. · Scientific reports. 2016;6:31986.
New Approach in Translational Medicine: Effects of Electrolyzed Reduced Water (ERW) on NF-κB/iNOS Pathway in U937 Cell Line under Altered Redox State
Franceschelli S, Gatta DM, Pesce M, Ferrone A, Patruno A, de Lutiis MA, Grilli A, Felaco M, Croce F, Speranza L. · International journal of molecular sciences. 2016;17(9):E1461.
Protective Effects of Hydrogen against Low-Dose Long-Term Radiation-Induced Damage to the Behavioral Performances, Hematopoietic System, Genital System, and Splenic Lymphocytes in Mice
Guo J, Zhao D, Lei X, Zhao H, Yang Y, Zhang P, Liu P, Xu Y, Zhu M, Liu H, Chen Y, Chuai Y, Li B, Gao F, Cai J. · 2016.
Radio-protective effect of hydrogen rich water combined with amifostine in mice
Qin X, Yin J, Li J, Qin A, Wen J, Niu QL. · International Journal of Radiation Research. 2016;14(2):113–118.
Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease
Qian LR, Shen JL. · Medical Gas Research. 2016;6(3):177–179.
Drinking Hydrogen-Rich Water Has Additive Effects on Non-Surgical Periodontal Treatment of Improving Periodontitis: A Pilot Study
Azuma T et al. · Antioxidants (Basel). 2015;4(3):513–522.
Hydrogen improves neurological function through attenuation of blood-brain barrier disruption in spontaneously hypertensive stroke-prone rats.
Takeuchi S, Nagatani K, Otani N, Nawashiro H, Sugawara T, Wada K, Mori K. · 2015.
Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice
Zhang JY et al. · World J Gastroenterol. 2015;21(14):4195–4209.
Hydrogen–water enhances 5-fluorouracil-induced inhibition of colon cancer
Runtuwene J, Amitani H, Amitani M, Asakawa A, Cheng KC, Inui A. · PeerJ. 2015;3:e859.
Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury
Nakano T, Kotani T, Mano Y, Tsuda H, Imai K, Ushida T, Li H, Miki R, Sumigama S, Sato Y, Iwase A, Hirakawa A, Asai M, Toyokuni S, Kikkawa F. · Journal of clinical biochemistry and nutrition. 2015;57(3):178-182.
Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water
Xue J, Shang G, Tanaka Y, Saihara Y, Hou L, Velasquez N, Liu W, Lu Y. · 2014.
Effects of hydrogen-rich water on aging periodontal tissues in rats
Tomofuji T et al. · Sci Rep. 2014;4:5534.
Molecular Hydrogen Attenuates Neuropathic Pain in Mice
Kawaguchi M, Satoh Y, Otsubo Y, Kazama T. · PloS one. 2014;9(6):e100352.
Positive effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice
Yoon YS, Sajo ME, Ignacio RM, Kim SK, Kim CS, Lee KJ. · Biol Pharm Bull. 2014;37(9):1480–1485.
Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction
Zhao S, Yang Y, Liu W, Xuan Z, Wu S, Yu S, Mei K, Huang Y, Zhang P, Cai J, Ni J, Zhao Y. · Journal of cellular and molecular medicine. 2014;18(5):938-946.
Protective role of hydrogen-rich water on aspirin-induced gastric mucosal damage in rats
Zhang JY, Wu QF, Wan Y, et al. · World Journal of Gastroenterology. 2014;20(6):1614–1622.
Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study
Ishibashi T et al. · Int Immunopharmacol. 2014;21(2):468–473.
Amelioration of cardio-renal injury with aging in dahl salt-sensitive rats by H2-enriched electrolyzed water.
Zhu WJ, Nakayama M, Mori T, Hao K, Terawaki H, Katoh J, Kabayama S, Ito S. · Medical Gas Research. 2013;3:26.
Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B
Xia C, Liu W, Zeng D, Zhu L, Sun X, Sun X. · Clinical and Translational Science. 2013;6(5):372–375.
Effect of Treadmill Exercise and Hydrogen-rich Water Intake on Serum Oxidative and Anti-oxidative Metabolites in Serum of Thoroughbred Horses.
Tsubone H, Hanafusa M, Endo M, Manabe N, Hiraga A, Ohmura H, Aida H. · Journal of Equine Science. 2013;24:1-8.
Hydrogen water consumption prevents osteopenia in ovariectomized rats
Guo JD, Li L, Shi YM, Wang HD, Hou SX. · British Journal of Pharmacology. 2013;168(6):1412-1420.
Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro
Li Q, Kato S, Matsuoka D, Tanaka H, Miwa N. · Medical gas research. 2013;3(1):20.