Effects of long-term hydrogen intervention on the physiological function of rats
Xun ZM, Zhao QH, Zhang Y, Ju FD, He J, Yao TT, Zhang XK, Yi Y, Ma SN, Zhao PX, Jin XY, Li YX, Li XY, Ma XM, Xie F. · Scientific reports. 2020;10(1):18509.
Hydrogen-rich water research
Browse 220 source-checked molecular hydrogen records classified as hydrogen-rich water, with human and preclinical evidence separated.
220full-text-checked records
73human studies
147animal and laboratory records
No treatment conclusion is impliedAdministration routes, concentrations, doses and treatment schedules vary and must not be treated as interchangeable. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.
Hydrogen in Patients With Corticosteroid-Refractory/Dependent Chronic Graft-Versus-Host-Disease: A Single-Arm, Multicenter, Open-Label, Phase 2 Trial
Qian L, Liu M, Shen J, Cen J, Zhao D. · Frontiers in Immunology. 2020;11:598359.
Hydrogen water alleviates paraquat-induced lung fibroblast injury in vitro by enhancing Nrf2 expression
Li T, Deng S, Lei W, Li Z, Wu W, Zhang T, Dong Z. · Journal of Southern Medical University. 2020;40(2):233-239.
Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: a randomized, double-blind, controlled trial
Sim M et al. · Sci Rep. 2020;10(1):12130.
Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males
Dobashi S et al. · Med Gas Res. 2020;10(1):21–26.
Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial
Ishibashi T et al. · PLoS One. 2020;15(5):e0233484.
Protective Effects of Hydrogen-Rich Water Against Cartilage Damage in a Rat Model of Osteoarthritis by Inhibiting Oxidative Stress, Matrix Catabolism, and Apoptosis
Cheng S, Peng L, Xu B, Chen W, Chen Y, Gu Y. · Medical science monitor : international medical journal of experimental and clinical research. 2020;26:e920211.
Protective effects of molecular hydrogen on hepatotoxicity induced by sub-chronic exposure to chlorpyrifos in rats
Xun ZM, Xie F, Zhao PX, Liu MY, Li ZY, Song JM, Kong XM, Ma XM, Li XY. · Ann Agric Environ Med. 2020;27(3):368–373.
RNA sequencing analysis reveals apoptosis induction by hydrogen treatment in endometrial cancer via TNF and NF-κB pathways
Yang Y, Liu YP, Bao W, Chen JS, Xi XW. · Translational cancer research. 2020;9(5):3468-3482.
The Effects of 24-Week, High-Concentration Hydrogen-Rich Water on Body Composition, Blood Lipid Profiles and Inflammation Biomarkers in Men and Women with Metabolic Syndrome: A Randomized Controlled Trial
LeBaron TW et al. · Diabetes Metab Syndr Obes. 2020;13:889–896.
The Effects of Supersaturated Hydrogen-Rich Water Bathing on Biomarkers of Muscular Damage and Soreness Perception in Young Men Subjected to High-Intensity Eccentric Exercise
Todorovic N, Javorac D, Stajer V, Ostojic SM. · Journal of sports medicine (Hindawi Publishing Corporation). 2020;2020:8836070.
Two-week continuous supplementation of hydrogen-rich water increases peak oxygen uptake during an incremental cycling exercise test in healthy humans: a randomized, single-blinded, placebo-controlled study
Hori A et al. · Med Gas Res. 2020;10(4):163–169.
Attenuation of Cardiac Ischaemia-reperfusion Injury by Treatment with Hydrogen-rich Water
Li X, Li L, Liu X, Wu J, Sun X, Li Z, Geng YJ, Liu F, Zhou Y. · Current molecular medicine. 2019;19(4):294-302.
Effects of hydrogen-rich water in a rat model of polycystic kidney disease
Yamasaki M, Miyazono M, Yoshihara M, Suenaga A, Mizuta M, Fukuda M, Rikitake S, Ikeda Y. · PloS one. 2019;14(4):e0215766.
Effects of Molecular Hydrogen on Methamphetamine-Induced Neurotoxicity and Spatial Memory Impairment
Wen D, Hui R, Wang J, Shen X, Xie B, Gong M, Yu F, Cong B, Ma C. · Frontiers in pharmacology. 2019;10:823.
Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation
Uto K, Sakamoto S, Que W, Shimata K, Hashimoto S, Sakisaka M, Narita Y, Yoshii D, Zhong L, Komohara Y, Li XK, Inomata Y, Hibi T. · BMC gastroenterology. 2019;19(1):25.
Intake of Molecular Hydrogen in Drinking Water Increases Membrane Transporters, p -Glycoprotein, and Multidrug Resistance-Associated Protein 2 without Affecting Xenobiotic-Metabolizing Enzymes in Rat Liver
Yao HT, Yang YH, Li ML. · Molecules (Basel, Switzerland). 2019;24(14):E2627.
Positive effect of an electrolyzed reduced water on gut permeability, fecal microbiota and liver in an animal model of Parkinson’s disease
Bordoni L, Gabbianelli R, Fedeli D, Fiorini D, Bergheim I, Jin CJ, Marinelli L, Di Stefano A, Nasuti C. · PloS one. 2019;14(10):e0223238.
Protein chip and bioinformatic analyses of differentially expressed proteins involved in the effect of hydrogen-rich water on myocardial ischemia-reperfusion injury
Li L, Liu T, Li X, Liu X, Liu L, Li S, Li Z, Zhou Y, Liu F. · International journal of medical sciences. 2019;16(9):1254-1259.
The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats
Zhou P, Lin B, Wang P, Pan T, Wang S, Chen W, Cheng S, Liu S. · Journal of radiation research. 2019;60(1):17-22.
Administration of hydrogen-rich water prevents vascular aging of the aorta in LDL receptor-deficient mice
Iketani M, Sekimoto K, Igarashi T, Takahashi M, Komatsu M, Sakane I, Takahashi H, Kawaguchi H, Ohtani-Kaneko R, Ohsawa I. · Scientific reports. 2018;8(1):16822.
Effect of molecular hydrogen on uterine inflammation during preterm labour
Nakano T, Kotani T, Imai K, Iitani Y, Ushida T, Tsuda H, Li H, Iwase A, Toyokuni S, Kikkawa F. · Biomedical Reports. 2018;8(5):454-460.
Effects of alkaline-electrolyzed and hydrogen-rich water, in a high-fat-diet nonalcoholic fatty liver disease mouse model
Jackson K, Dressler N, Ben-Shushan RS, Meerson A, LeBaron TW, Tamir S. · World journal of gastroenterology. 2018;24(45):5095-5108.
Effects of hydrogen rich water on prolonged intermittent exercise
Da Ponte A et al. · J Sports Med Phys Fitness. 2018;58(5):612–621.