Molecular hydrogen ameliorates anti-desmoglein 1 antibody-induced pemphigus-associated interstitial lung disease by inhibiting oxidative stress
Tang C et al. · Int J Mol Sci. 2025;26(9):4203.
Hydrogen-rich water research
Browse 220 source-checked molecular hydrogen records classified as hydrogen-rich water, with human and preclinical evidence separated.
220full-text-checked records
73human studies
147animal and laboratory records
No treatment conclusion is impliedAdministration routes, concentrations, doses and treatment schedules vary and must not be treated as interchangeable. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.
Molecular Hydrogen Modulates T Cell Differentiation and Enhances Neuro-Regeneration in a Vascular Dementia Mouse Model
Lee D, Jo H, Choi JI. · Antioxidants (Basel, Switzerland). 2025;14(1):111.
Multifunctional PdH-hydride MOFs for synergistic hydrogen and photothermal antibacterial therapy in accelerated wound healing
Wang Q, Zhang D, Qi Y, Huang C, Ding D, Liu C. · Frontiers in pharmacology. 2025;16:1587890.
Nrf2/HO-1-sulfiredoxin1 pathway involved in nanobubble hydrogen-dissolved water-mediated protective effects by ultrasound-guided early local injection in a rat model of chronic constriction injury-induced neuropathic pain
Yu J, Yin Z, Ma H, Zhang B, Meng C. · Frontiers in molecular neuroscience. 2025;18:1666575.
Optimized dose of hydrogen-enriched water with minocycline combination therapy in experimental ischemic stroke
Jiang Z, Alamuri TT, Yang DL, Annarino T, Muir ER, Duong TQ. · Brain Research. 2025;1866:149940.
Pre-Exercise Ingestion of Hydrogen-Rich Cold Water Enhances Endurance Performance and Lactate Response in Heat
Khlifi M, Jebabli N, Ouerghi N, Yagin FH, Dutta AK, Alwhaibi R, Bouassida A. · Medicina (Kaunas). 2025;61(7):1173.
Preventing Cisplatin-Induced Neuropathy and Related Emotional Disorders with the Coadministration of Duloxetine and Hydrogen-Rich Water in Male and Female Mice
Martínez-Martel I, Negrini-Ferrari SE, Pol O. · Antioxidants (Basel, Switzerland). 2025;14(8):1004.
Radio-protective effects of ultra-fine bubble hydrogen water and serum protein responses in whole-body radiation-exposed mice
Yamaguchi M, Htun KT, Tatara Y, Sato Y, Hosoda M, Kothan S, Kamimura C, Inanami O, Kashiwakura I. · Scientific reports. 2025;15(1):4447.
The Effects of 8-Week Hydrogen-Rich Water Consumption on Appetite, Body Composition, Sleep Quality, and Circulating Glucagon-like Peptide-1 in Obese Men and Women (HYDRAPPET): A Randomized Controlled Trial
Todorovic N et al. · Medicina (Kaunas). 2025;61(7):1299.
The gastroprotective effect of hydrogen-rich coral calcium in a mouse model of peptic ulcer disease
Wu HT, Hsieh MT, Ou HY, Chao TH, Tsai LM. · Drug Design, Development and Therapy. 2025;19:9845–9851.
The Rieske iron-sulfur protein is a primary target of molecular hydrogen
Negishi S, Ito M, Hasegawa T, Otake H, Ohkawara B, Masuda A, Mino H, LeBaron TW, Ohno K. · Redox biology. 2025;88:103952.
Treatment with hydrogen-rich water protects against thioacetamide-induced hepatic encephalopathy in rats through stabilizing liver–brain disturbance
Wang X, Liu X, Zhou P, Feng J, Jia J, Xie B, Chen Y, Zhou J. · Scientific reports. 2025;15(1):17901.
Anti-Inflammatory and Bacteriostatic Effects of Hydrogen-Rich Water on Rats With Periodontitis
Bai Y, Zhao L, Wang L, Shan Y, Zhang W, Wen N. · Journal of Food Biochemistry. 2024:5917799.
Effects of 8 days intake of hydrogen-rich water on muscular endurance performance and fatigue recovery during resistance training
Zhou K et al. · Front Physiol. 2024;15:1458882.
Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: A randomized placebo-controlled trial
Wu F et al. · Heliyon. 2024;10(16):e36401.
Health Effects of Electrolyzed Hydrogen Water for the Metabolic Syndrome and Pre-Metabolic Syndrome: A 3-Month Randomized Controlled Trial and Subsequent Analyses
Moribe R, Minami M, Hirota R, et al. · Antioxidants. 2024;13(2):145.
Hydrogen alleviates hypoxic-ischaemic brain damage in neonatal rats by inhibiting injury of brain pericytes.
Li H, Sun H, Li S, Huang L, Zhang M, Wang S, Liu Q, Ying J, Zhao F, Su X, Mu D, Qu Y. · 2024.
Hydrogen-Rich Water (HRW) Reduces Fatty Acid-Induced Lipid Accumulation and Oxidative Stress Damage through Activating AMP-Activated Protein Kinase in HepG2 Cells
Tsou SH, Lin SC, Chen WJ, Hung HC, Liao CC, Kornelius E, Huang CN, Lin CL, Yang YS. · Biomedicines. 2024;12(7):1444.
Hydrogen-rich water alleviates constipation by attenuating oxidative stress through the sirtuin1/nuclear factor-erythroid-2-related factor 2/heme oxygenase-1 signaling pathway
Chen KD, Wang KL, Chen C, Zhu YJ, Tang WW, Wang YJ, Chen ZP, He LH, Chen YG, Zhang W. · World J Gastroenterol. 2024;30(20):2709–2725.
Hydrogen-rich water improves sleep consolidation and enhances forebrain neuronal activation in mice
Vincent SM et al. · Sleep Adv. 2024;5(1):zpad057.
Hydrogen-rich water supplementation promotes muscle recovery after two strenuous training sessions performed on the same day in elite fin swimmers
Sládečková B et al. · Front Physiol. 2024;15:1321160.
Molecular Hydrogen for Outpatients with COVID-19 (Hydro-COVID): A Phase 3 Randomised, Triple-Blinded, Pragmatic, Placebo-Controlled, Multicentre Trial
Gaboreau Y et al. · J Clin Med. 2024;13(15):4308.
Morphofunctional characteristics of the liver and kidneys of Chinchilla lanigera during consumption of water enriched with molecular hydrogen
Panina EV, Karkishchenko VN, Ostrenko KS, Petrov DV, Sorochan AE. · Journal Biomed. 2024;20(3E):70–76.
Oral Intake of Hydrogen Water Improves Retinal Blood Flow Dysregulation in Response to Flicker Stimulation and Systemic Hyperoxia in Diabetic Mice
Sugiyama R, Hanaguri J, Yokota H, Kushiyama A, Kushiyama S, Kikuchi T, Igarashi T, Iketani M, Ohsawa I, Harino S, Nakashizuka H, Yamagami S, Nagaoka T. · Translational vision science & technology. 2024;13(10):36.