Efficacy and Safety of Hydrogen Therapy in Patients with Early-Stage Interstitial Lung Disease
Tang C et al. · Ther Clin Risk Manag. 2023;19:1051–1061.
Molecular hydrogen (H2) and Respiratory health
Browse 62 source-checked respiratory health records involving molecular hydrogen (H2), with human and preclinical evidence clearly separated.
62full-text-checked records
17human studies
45animal and laboratory records
No treatment conclusion is impliedSymptoms, pulmonary function, clinical events and inflammation-related measures are considered separately. Every result must be interpreted in the context of its design, population or model, intervention, comparator and measured outcome.
Hydrogen inhalation attenuates lung contusion after blunt chest trauma in mice
Ageta K et al. · Surgery. 2023;174(2):343-349.
The Anti-inflammatory Effects of Hydrogen-Rich Water Acts in a Volume-Dependent Manner on Rats' Lungs Exposed to Cigarette Smoke
Rahmatullah AS, Santoso A, Cangara MH, Yustisia I, Aminuddin, Adnan E. · JUMANTIK. 2023;8(2):197–206.
The efficacy of hydrogen/oxygen therapy favored the recovery of omicron SARS-CoV-2 variant infection: results of a multicenter, randomized, controlled trial
Shi MM, Chen YT, Wang XD, et al. · Journal of Clinical Biochemistry and Nutrition. 2023;73(3):228–233.
Hydrogen gas alleviates lipopolysaccharide-induced acute lung injury and inflammatory response in mice
Yin H et al. · J Inflamm (Lond). 2022;19:16.
Hydrogen-rich water alleviates inflammation and fatigue in COVID-19: A pilot study
Milovancev A, Avakumovic J, Drid P, Todorovic N, Stajer V, Ostojic SM. · European Journal of Inflammation. 2022;20.
Magnesium hydride ameliorates endotoxin-induced acute respiratory distress syndrome by inhibiting inflammation, oxidative stress, and cell apoptosis
Shi X, Zhu L, Wang S, Zhu W, Li Q, Wei J, Feng D, Liu M, Chen Y, Sun X, Lu H, Lv X. · Oxidative Medicine and Cellular Longevity. 2022;2022:5918954.
Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response
Hasegawa T, Ito M, Hasegawa S, Teranishi M, Takeda K, Negishi S, Nishiwaki H, Takeda JI, LeBaron TW, Ohno K. · International journal of molecular sciences. 2022;23(5):2888.
The effects of hydrogen treatment in a cigarette smoke solution-induced chronic obstructive pulmonary disease-like changes in an animal model
Yang HJ, Tsou WH, Shen MC, Liu CY, Saunders HM, Wang KY, Douglas FL. · Journal of thoracic disease. 2022;14(11):4246-4255.
Antioxidant Properties of Hydrogen Gas Attenuates Oxidative Stress in Airway Epithelial Cells
You IS, Sharma S, Fadriquela A, Bajgai J, Thi TT, Rahman MH, Sung J, Kwon HU, Lee SY, Kim CS, Lee KJ. · Molecules (Basel, Switzerland). 2021;26(21):6375.
Hydrogen Attenuates Endotoxin-Induced Lung Injury by Activating Thioredoxin 1 and Decreasing Tissue Factor Expression
Li Q, Hu L, Li J, Yu P, Hu F, Wan B, Xu M, Cheng H, Yu W, Jiang L, Shi Y, Li J, Duan M, Long Y, Liu WT. · 2021.
Hydrogen-rich saline regulates the polarization and apoptosis of alveolar macrophages and attenuates lung injury via suppression of autophagy in septic rats
Qiu P, Liu Y, Chen K, Dong Y, Liu S, Zhang J. · Annals of translational medicine. 2021;9(12):974.
Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial
Zheng ZG, Sun WZ, Hu JY, Jie ZJ, Xu JF, Cao J, Song YL, Wang CH, Wang J, Zhao H, Guo ZL, Zhong NS. · Respiratory Research. 2021;22:149.
The effects of inhaling hydrogen gas on macrophage polarization, fibrosis and lung function in mice with bleomycin-induced lung injury
Aokage T et al. · BMC Pulm Med. 2021;21:339.
Changes of nasal nitric oxide in the treatment of allergic rhinitis with hydrogen-rich saline lavage of nasal cavity
Jin L, Fan K, Zhang X, Zhao Y, Ge Q, Wang Y, Yu S. · Journal of Clinical Otorhinolaryngology Head and Neck Surgery. 2020;34(3):244–247.
Hydrogen gas (XEN) inhalation ameliorates airway inflammation in asthma and COPD patients
Wang ST et al. · QJM. 2020;113(12):870–875.
Hydrogen water alleviates paraquat-induced lung fibroblast injury in vitro by enhancing Nrf2 expression
Li T, Deng S, Lei W, Li Z, Wu W, Zhang T, Dong Z. · Journal of Southern Medical University. 2020;40(2):233-239.
Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial
Guan WJ, Wei CH, Chen AL, Sun XC, Guo GY, Zou X, Shi JD, Lai PZ, Zheng ZG, Zhong NS. · Journal of Thoracic Disease. 2020;12(6):3448.
Low-Flow Nasal Cannula Hydrogen Therapy
Sano M et al. · J Clin Med Res. 2020;12(10):674–680.
Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis
Liu L, Yan Z, Wang Y, Meng J, Chen G. · Oncology letters. 2020;20(4):112.
Brain Metastases Completely Disappear in Non-Small Cell Lung Cancer Using Hydrogen Gas Inhalation: A Case Report
Chen J, Mu F, Lu T, Du D, Xu K. · OncoTargets and therapy. 2019;12:11145-11151.
Effect of H_2 treatment in a mouse model of rheumatoid arthritis‐associated interstitial lung disease
Terasaki Y, Terasaki M, Kanazawa S, Kokuho N, Urushiyama H, Kajimoto Y, Kunugi S, Maruyama M, Akimoto T, Miura Y, Igarashi T, Ohsawa I, Shimizu A. · Journal of cellular and molecular medicine. 2019;23(10):7043-7053.
Hydrogen-rich saline ameliorated LPS-induced acute lung injury via autophagy inhibition through the ROS/AMPK/mTOR pathway in mice
Wang Y, Zhang J, Bo J, Wang X, Zhu J. · Experimental Biology and Medicine. 2019;244(9):721-727.
Hydrogen gas inhalation protects against cigarette smoke-induced COPD development in mice
Lu W, Li D, Hu J, Mei H, Shu J, Long Z, Yuan L, Li D, Guan R, Li Y, Xu J, Wang T, Yao H, Zhong N, Zheng Z. · Journal of Thoracic Disease. 2018;10(6):3232–3243.